Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4284474 | 0.90 | GRM4 (0.47) | ALDH1A1KDM4EHTTKDM4CL3MBTL1 | |
| SCHEMBL4281447 | 0.90 | TSHR (0.51) | ALDH1A1KDM4ESMN1; SMN2KMT2AHPGD | |
| SCHEMBL4279961 | 0.88 | KMT2A (0.51) | ALDH1A1KDM4EL3MBTL1SMN1; SMN2KMT2A | |
| SCHEMBL4279807 | 0.87 | SMN1; SMN2 (0.49) | ALDH1A1KDM4EHTTKDM4CL3MBTL1 | |
| SCHEMBL4287145 | 0.86 | SMN1; SMN2 (0.46) | ALDH1A1KDM4EHTTKDM4CL3MBTL1 | |
| SCHEMBL4279912 | 0.86 | KMT2A (0.51) | ALDH1A1KDM4EHTTKDM4CL3MBTL1 | |
| SCHEMBL4279804 | 0.86 | SMN1; SMN2 (0.55) | ALDH1A1KDM4EHTTKDM4CL3MBTL1 | |
| SCHEMBL4281573 | 0.86 | L3MBTL1 (0.49) | ALDH1A1KDM4EHTTKDM4CL3MBTL1 | |
| SCHEMBL4281575 | 0.85 | RAB9A (0.48) | ALDH1A1KDM4EHTTSMN1; SMN2KMT2A | |
| SCHEMBL4290849 | 0.84 | NPC1 (0.47) | ALDH1A1SMN1; SMN2KMT2AHPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090156582-A1 | Pyrazole Compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-06-18 | — | — | US | disclosed |
| EP-1847531-A1 | PYRAZOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2007-10-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156582-A1 | Pyrazole Compound | GSK3B, GSK3A, GSKIP | ALDH1A1 694/4885KDM4E 810/4885HTT 4201/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.