Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 9/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | PTPRF | P10586 | 1/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1007555 | 1.00 | HTR3A (0.61) | HTR3AKCNH2PTPRFPTPN2PTPN1 | |
| SCHEMBL4293502 | 1.00 | HTR3A (0.61) | HTR3AKCNH2PTPRFPTPN2PTPN1 | |
| SCHEMBL3990473 | 0.87 | HTR3A (0.61) | HTR3AKCNH2KDM4EHCRTR1HCRTR2 | |
| SCHEMBL1005033 | 0.87 | HTR3A (0.61) | HTR3AKCNH2KDM4EHCRTR1HCRTR2 | |
| SCHEMBL3990476 | 0.87 | HTR3A (0.61) | HTR3AKCNH2KDM4EHCRTR1HCRTR2 | |
| SCHEMBL1004342 | 0.80 | HTR6 (0.58) | HTR3AKCNH2LMNAIDO1MAOA | |
| SCHEMBL1004884 | 0.79 | HTR6 (0.50) | HTR3AKCNH2LMNAIDO1MAOA | |
| SCHEMBL1004465 | 0.78 | HTR3A (0.76) | HTR3AKCNH2 | |
| SCHEMBL1004466 | 0.78 | HTR3A (0.66) | HTR3AKCNH2CYP2C19 | |
| SCHEMBL1004467 | 0.78 | HTR3A (0.76) | HTR3AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061460-A2 | 2-AMINOBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS | Albany Molecular Research, Inc. (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008019372-A2 | 2-AMINOBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS | ALBANY MOLECULAR RESEARCH, INC. (US) | 2008-02-14 | — | — | WO | disclosed |