Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 15/20 | 1.00 |
| ▸ | DRD3 | P35462 | 15/20 | 1.00 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.61 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4294300 | 1.00 | DRD2 (1.00) | DRD2DRD3HDAC3HDAC1HDAC6 | |
| SCHEMBL29914813 | 1.00 | DRD2 (1.00) | DRD2DRD3HDAC3HDAC1HDAC6 | |
| SCHEMBL7851097 | 0.90 | DRD2 (0.81) | DRD2DRD3HDAC3HDAC1HDAC6 | |
| SCHEMBL7851948 | 0.90 | DRD2 (0.81) | DRD2DRD3HDAC3HDAC1HDAC6 | |
| SCHEMBL7852040 | 0.86 | DRD2 (0.78) | DRD2DRD3 | |
| SCHEMBL7852036 | 0.86 | DRD2 (0.78) | DRD2DRD3 | |
| SCHEMBL7851643 | 0.83 | DRD2 (1.00) | DRD2DRD3 | |
| SCHEMBL7851769 | 0.83 | DRD2 (1.00) | DRD2DRD3 | |
| SCHEMBL2840972 | 0.83 | DRD3 (0.72) | DRD2DRD3HDAC3HDAC1HDAC2 | |
| SCHEMBL7850257 | 0.83 | DRD2 (0.72) | DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090209551-A1 | ESSENTIAL TREMOR DIAGNOSTIC AND TREATMENT | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2009-08-20 | — | — | US | claimed |
| EP-1591455-A1 | Essential tremor diagnostic and treatment | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2005-11-02 | — | — | EP | claimed |
| US-20090209551-A1 | ESSENTIAL TREMOR DIAGNOSTIC AND TREATMENT | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2009-08-20 | — | — | US | disclosed |
| EP-1740610-A2 | ESSENTIAL TREMOR DIAGNOSTIC AND TREATMENT | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005105839-A2 | ESSENTIAL TREMOR DIAGNOSTIC AND TREATMENT | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2005-11-10 | — | — | WO | disclosed |
| EP-1591455-A1 | Essential tremor diagnostic and treatment | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2005-11-02 | — | — | EP | disclosed |
| WO-2004084952-A1 | IN VIVO METHOD FOR DETECTING DOPAMINE D3 RECEPTORS LIGANDS. | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2004-10-07 | — | — | WO | disclosed |
| EP-1462117-A1 | Method for in vivo detection of antipsychotic properties of dopamine D3 receptor ligands | Institut National de la Santé et de la Recherche Médicale (INSERM) (FR) | 2004-09-29 | — | — | EP | disclosed |