Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 4/20 | 0.72 |
| ▸ | DRD2 | P14416 | 3/20 | 0.72 |
| ▸ | HTR7 | P34969 | 4/20 | 0.63 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.62 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.62 |
| ▸ | HTR1A | P08908 | 2/20 | 0.61 |
| ▸ | HTR2A | P28223 | 1/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.61 |
| ▸ | HRH1 | P35367 | 1/20 | 0.61 |
| ▸ | HTR2B | P41595 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.60 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20502177 | 0.96 | DRD2 (0.66) | DRD3DRD2HTR7HDAC3HDAC1 | |
| SCHEMBL27246707 | 0.90 | HDAC3 (0.61) | DRD3DRD2HTR7HDAC3HDAC1 | |
| SCHEMBL14722227 | 0.88 | DRD2 (0.86) | DRD3DRD2HTR7HDAC3HDAC1 | |
| SCHEMBL7843315 | 0.84 | DRD3 (0.63) | DRD3DRD2HTR7HDAC3HDAC1 | |
| SCHEMBL15835899 | 0.84 | DRD2 (0.80) | DRD3DRD2HTR7HTR1AHTR2A | |
| SCHEMBL13135921 | 0.83 | CYP2D6 (0.63) | DRD3DRD2HTR7HDAC3HDAC1 | |
| SCHEMBL29914813 | 0.83 | DRD2 (1.00) | DRD3DRD2HDAC3HDAC1HDAC8 | |
| SCHEMBL4294293 | 0.83 | DRD2 (1.00) | DRD3DRD2HDAC3HDAC1HDAC8 | |
| SCHEMBL4294300 | 0.83 | DRD2 (1.00) | DRD3DRD2HDAC3HDAC1HDAC8 | |
| SCHEMBL19957570 | 0.82 | ALDH1A1 (0.71) | DRD3DRD2HTR7HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2251324-A1 | HETEROARYL-ALKYLCARBAMATE COMPOUNDS AND THEIR USE AS INHIBITORS OF THE FAAH ENZYME | Sanofi-Aventis (FR) | 2010-11-17 | — | — | EP | disclosed |
| EP-1720829-B1 | DERIVATIVES OF HETEROARYL-ALKYLCARBAMATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS | SANOFI AVENTIS (FR) | 2009-10-14 | — | — | EP | disclosed |
| EP-1720829-A1 | DERIVATIVES OF HETEROARYL-ALKYLCARBAMATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS | Sanofi-Aventis (FR) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005090292-A1 | DERIVATIVES OF HETEROARYL-ALKYLCARBAMATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS | SANOFI-AVENTIS (FR) | 2005-09-29 | — | — | WO | disclosed |