Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CASR | P41180 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | SELP | P16109 | 1/20 | 0.49 |
| ▸ | SELE | P16581 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.47 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.47 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4289827 | 0.87 | KDM4E (0.64) | ALDH1A1KDM4ESMN1; SMN2LMNANPC1 | |
| SCHEMBL3378244 | 0.87 | ALDH1A1 (0.51) | ALDH1A1KDM4ESMN1; SMN2LMNANPC1 | |
| SCHEMBL29543730 | 0.84 | KMT2A (0.70) | ALDH1A1KDM4ESMN1; SMN2LMNANPC1 | |
| SCHEMBL111479 | 0.84 | KMT2A (0.70) | ALDH1A1KDM4ESMN1; SMN2LMNANPC1 | |
| Phenol SCHEMBL28121926 | 0.83 | KMT2A (0.64) | ALDH1A1KDM4ESMN1; SMN2LMNANPC1 | |
| SCHEMBL9958894 | 0.83 | ALDH1A1 (0.60) | ALDH1A1KDM4ESMN1; SMN2LMNANPC1 | |
| SCHEMBL2449980 | 0.83 | KDM4E (0.68) | ALDH1A1KDM4ESMN1; SMN2LMNAKMT2A | |
| SCHEMBL3633756 | 0.82 | SMN1; SMN2 (0.66) | ALDH1A1KDM4ESMN1; SMN2LMNAKMT2A | |
| SCHEMBL4290828 | 0.81 | KDM4E (0.59) | ALDH1A1KDM4ESMN1; SMN2LMNANPC1 | |
| SCHEMBL30810149 | 0.80 | ALDH1A1 (0.63) | ALDH1A1KDM4ESMN1; SMN2LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090203770-A1 | COMPOSITIONS AND METHODS FOR MODULATING APOPTOSIS IN CELLS OVER-EXPRESSING Bcl-2 FAMILY MEMBER PROTEINS | FRED HUTCHISON CANCER RESEARCH CENTER (US) | 2009-08-13 | — | — | US | disclosed |
| US-7241804-B1 | Compositions and methods for modulating apoptosis in cells over-expressing Bcl-2 family member proteins | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2007-07-10 | — | — | US | disclosed |
| EP-1218368-A4 | COMPOSITIONS AND METHODS FOR MODULATING APOPTOSIS IN CELLS OVER-EXPRESSING bcl-2 FAMILY MEMBER PROTEINS | HUTCHINSON FRED CANCER RES (US) | 2003-04-16 | — | — | EP | disclosed |
| EP-1218368-A1 | COMPOSITIONS AND METHODS FOR MODULATING APOPTOSIS IN CELLS OVER-EXPRESSING bcl-2 FAMILY MEMBER PROTEINS | Fred Hutchinson Cancer Research Center (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001014365-A1 | COMPOSITIONS AND METHODS FOR MODULATING APOPTOSIS IN CELLS OVER-EXPRESSING bcl-2 FAMILY MEMBER PROTEINS | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2001-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203770-A1 | COMPOSITIONS AND METHODS FOR MODULATING APOPTOSIS IN CELLS OVER-EXPRESSING Bcl-2 FAMILY MEMBER PROTEINS | BCL2, BAX, BCL2A1 | ALDH1A1 4187/4885KDM4E 4139/4885SMN1; SMN2 1953/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.