Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.60 |
| ▸ | SELP | P16109 | 1/20 | 0.59 |
| ▸ | SELE | P16581 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 6/20 | 0.57 |
| ▸ | RAB9A | P51151 | 6/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.57 |
| ▸ | CASP3 | P42574 | 2/20 | 0.57 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.57 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.57 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15329661 | 0.85 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2SELPSELENPC1 | |
| SCHEMBL29623849 | 0.85 | BTK (0.57) | ALDH1A1SMN1; SMN2SELPSELENPC1 | |
| SCHEMBL7235813 | 0.85 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2SELPSELENPC1 | |
| SCHEMBL4565885 | 0.84 | SELP (0.61) | ALDH1A1SMN1; SMN2SELPSELENPC1 | |
| SCHEMBL29543730 | 0.84 | KMT2A (0.70) | ALDH1A1SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL111479 | 0.84 | KMT2A (0.70) | ALDH1A1SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL4294304 | 0.83 | ALDH1A1 (0.68) | ALDH1A1SMN1; SMN2SELPSELENPC1 | |
| SCHEMBL10987960 | 0.82 | SOAT1 (0.59) | ALDH1A1SMN1; SMN2SELPSELENPC1 | |
| SCHEMBL10981533 | 0.82 | SOAT1 (0.59) | ALDH1A1SMN1; SMN2SELPSELENPC1 | |
| SCHEMBL10982243 | 0.82 | SOAT1 (0.59) | ALDH1A1SMN1; SMN2SELPSELENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655335-A1 | NOVEL IMIDAZOLE-2-BENZAMIDE COMPOUNDS USEFUL FOR THE TREATMENT OF OSTEOARTHRITIS | Eli Lilly and Company (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087771-A1 | NOVEL IMIDAZOLE-2-BENZAMIDE COMPOUNDS USEFUL FOR THE TREATMENT OF OSTEOARTHRITIS | ELI LILLY AND COMPANY (US) | 2012-06-28 | — | — | WO | disclosed |