Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGFRL1 | Q5TC84 | 11/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 10/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 10/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 8/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4281769 | 0.83 | OGFRL1 (0.53) | OGFRL1OPRM1OPRK1OPRD1GAA | |
| SCHEMBL4291351 | 0.79 | OGFRL1 (0.44) | OGFRL1OPRM1OPRK1OPRD1OPRL1 | |
| SCHEMBL4819129 | 0.78 | OGFRL1 (0.43) | OGFRL1OPRM1OPRK1OPRD1OPRL1 | |
| SCHEMBL5014189 | 0.72 | GAA (0.44) | OGFRL1OPRM1OPRK1OPRD1GAA | |
| SCHEMBL3494784 | 0.70 | OGFRL1 (0.44) | OGFRL1OPRM1OPRK1MDM2GAA | |
| SCHEMBL4284918 | 0.69 | OGFRL1 (0.53) | OGFRL1OPRM1OPRK1OPRD1GAA | |
| SCHEMBL885834 | 0.69 | MEN1 (0.46) | OGFRL1OPRM1OPRK1OPRD1GAA | |
| SCHEMBL5014105 | 0.68 | GAA (0.42) | OGFRL1OPRM1OPRK1OPRD1OPRL1 | |
| SCHEMBL5013554 | 0.68 | GAA (0.42) | GAAALOX15CNR1HCAR1MEN1 | |
| SCHEMBL1128699 | 0.67 | TP53 (0.56) | OGFRL1OPRM1OPRK1OPRD1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227560-A1 | Substituted imidazole compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-09-10 | — | — | US | disclosed |
| US-20090227560-A1 | Substituted imidazole compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-09-10 | — | — | US | disclosed |
| US-20090227560-A1 | Substituted imidazole compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-09-10 | — | — | US | disclosed |
| US-20090156612-A1 | Substituted imidazole compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-06-18 | — | — | US | disclosed |
| US-20090156612-A1 | Substituted imidazole compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-06-18 | — | — | US | disclosed |
| US-20090156612-A1 | Substituted imidazole compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-06-18 | — | — | US | disclosed |
| WO-2008139941-A1 | SUBSTITUTED IMIDAZOLE COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156612-A1 | Substituted imidazole compound and use thereof | REN, ACE, AGT | OGFRL1 2785/4885OPRM1 3919/4885OPRK1 2640/4885 |
| US-20090227560-A1 | Substituted imidazole compound and use thereof | REN, ACE, AGT | OGFRL1 2785/4885OPRM1 3919/4885OPRK1 2640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.