Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.54 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.42 |
| ▸ | ARG1 | P05089 | 4/20 | 0.40 |
| ▸ | CPB2 | Q96IY4 | 3/20 | 0.40 |
| ▸ | CPB1 | P15086 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | ARG2 | P78540 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL28245493 | 1.00 | GSR (0.54) | GSRITGB3ITGA2BARG1CPB2 | |
| D-Histidine SCHEMBL902054 | 1.00 | GSR (0.54) | GSRITGB3ITGA2BARG1CPB2 | |
| Histidine SCHEMBL27440707 | 1.00 | GSR (0.54) | GSRITGB3ITGA2BARG1CPB2 | |
| Histidine SCHEMBL305856 | 1.00 | GSR (0.54) | GSRITGB3ITGA2BARG1CPB2 | |
| Histidine SCHEMBL305855 | 1.00 | GSR (0.54) | GSRITGB3ITGA2BARG1CPB2 | |
| Histidine SCHEMBL16714200 | 1.00 | GSR (0.54) | GSRITGB3ITGA2BARG1CPB2 | |
| Histidine SCHEMBL4297918 | 1.00 | GSR (0.54) | GSRITGB3ITGA2BARG1CPB2 | |
| Histidine SCHEMBL27767215 | 1.00 | GSR (0.54) | GSRITGB3ITGA2BARG1CPB2 | |
| Histidine SCHEMBL18419548 | 1.00 | GSR (0.54) | GSRITGB3ITGA2BARG1CPB2 | |
| Histidine SCHEMBL4735217 | 0.99 | GSR (0.53) | GSRITGB3ITGA2BARG1CPB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3103446-A2 | PHARMACEUTICAL PREPARATION FOR PREVENTING AND TREATING PROGRESSIVE MYOPIA | Zakharov, Ivan Dmitrievich (RU) | 2016-12-14 | — | — | EP | claimed |
| EP-3103446-B1 | PHARMACEUTICAL PREPARATION FOR PREVENTING AND TREATING PROGRESSIVE MYOPIA | ZAKHAROV IVAN DMITRIEVICH (RU) | 2024-02-14 | — | — | EP | disclosed |
| EP-3103446-A2 | PHARMACEUTICAL PREPARATION FOR PREVENTING AND TREATING PROGRESSIVE MYOPIA | Zakharov, Ivan Dmitrievich (RU) | 2016-12-14 | — | — | EP | disclosed |
| US-20130123330-A1 | Dual Targeted siRNA Therapeutics for Treatment of Diabetic Retinopathy and Other Ocular Neovascularization Diseases | LU PATRICK Y (US) | 2013-05-16 | — | — | US | disclosed |
| US-20090247604-A1 | RNAi Therapeutics for Treatment of Eye Neovascularization Diseases | INTRADIGM CORPORATION (US) | 2009-10-01 | — | — | US | disclosed |
| WO-2008154482-A2 | SIRNA COMPOSITIONS AND METHODS OF USE IN TREATMENT OF OCULAR DISEASES | SIRNAOMICS, INC. (US) | 2008-12-18 | — | — | WO | disclosed |
| CN-101199858-A | Multiple target point small interference RNA cocktail agent for treating ophthalmic disease and preparing method thereof | GUANGZHOU TOP GENOMICS LTD (CN) | 2008-06-18 | — | — | CN | disclosed |
| EP-1711510-A2 | RNAI THERAPEUTICS FOR TREATMENT OF EYE NEOVASCULARIZATION DISEASES | Intradigm Corporation (US) | 2006-10-18 | — | — | EP | disclosed |
| WO-2005076998-A2 | RNAI THERAPEUTICS FOR TREATMENT OF EYE NEOVASCULARIZATION DISEASES | INTRADIGM CORPORATION (US) | 2005-08-25 | — | — | WO | disclosed |