Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of D-Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.54 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.42 |
| ▸ | ARG1 | P05089 | 4/20 | 0.40 |
| ▸ | CPB2 | Q96IY4 | 3/20 | 0.40 |
| ▸ | CPB1 | P15086 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | ARG2 | P78540 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL28245493 | 1.00 | GSR (0.54) | GSRITGB3ITGA2BARG1CPB2 | |
| Histidine SCHEMBL4294462 | 1.00 | GSR (0.54) | GSRITGB3ITGA2BARG1CPB2 | |
| Histidine SCHEMBL27440707 | 1.00 | GSR (0.54) | GSRITGB3ITGA2BARG1CPB2 | |
| Histidine SCHEMBL305856 | 1.00 | GSR (0.54) | GSRITGB3ITGA2BARG1CPB2 | |
| Histidine SCHEMBL305855 | 1.00 | GSR (0.54) | GSRITGB3ITGA2BARG1CPB2 | |
| Histidine SCHEMBL16714200 | 1.00 | GSR (0.54) | GSRITGB3ITGA2BARG1CPB2 | |
| Histidine SCHEMBL4297918 | 1.00 | GSR (0.54) | GSRITGB3ITGA2BARG1CPB2 | |
| Histidine SCHEMBL27767215 | 1.00 | GSR (0.54) | GSRITGB3ITGA2BARG1CPB2 | |
| Histidine SCHEMBL18419548 | 1.00 | GSR (0.54) | GSRITGB3ITGA2BARG1CPB2 | |
| Histidine SCHEMBL4735217 | 0.99 | GSR (0.53) | GSRITGB3ITGA2BARG1CPB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9909088-B2 | Method for isomerisation of hop alpha-acids to iso-alpha-acids | IFAST NV (BE) | 2018-03-06 | — | — | US | disclosed |
| EP-2622060-B1 | IMPROVED METHOD FOR ISOMERISATION OF HOP ALPHA-ACIDS TO ISO-ALPHA-ACIDS | IFAST NV (BE) | 2015-05-20 | — | — | EP | disclosed |
| US-20130209653-A1 | METHOD FOR ISOMERISATION OF HOP ALPHA-ACIDS TO ISO-ALPHA-ACIDS | IFAST NV (BE) | 2013-08-15 | — | — | US | disclosed |
| EP-2622060-A1 | IMPROVED METHOD FOR ISOMERISATION OF HOP ALPHA-ACIDS TO ISO-ALPHA-ACIDS | Ifast NV (BE) | 2013-08-07 | — | — | EP | disclosed |
| WO-2012041994-A1 | IMPROVED METHOD FOR ISOMERISATION OF HOP ALPHA-ACIDS TO ISO-ALPHA-ACIDS | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2012-04-05 | — | — | WO | disclosed |