Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.51 |
| ▸ | FPR1 | P21462 | 2/20 | 0.50 |
| ▸ | ANXA2 | P07355 | 1/20 | 0.50 |
| ▸ | S100A10 | P60903 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 8/20 | 0.49 |
| ▸ | MDM2 | Q00987 | 8/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4302148 | 0.92 | KDM4E (0.53) | KDM4ERXFP1ALOX15MAPK10CYP1A2 | |
| SCHEMBL4301118 | 0.91 | PPARG (0.52) | KDM4ERXFP1ALOX15MAPK10CYP1A2 | |
| SCHEMBL4299757 | 0.89 | RXFP1 (0.51) | KDM4ERXFP1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4294215 | 0.86 | KDM4E (0.59) | KDM4ERXFP1ALOX15MAPK10CYP1A2 | |
| SCHEMBL4291443 | 0.85 | RXFP1 (0.62) | KDM4ERXFP1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4298543 | 0.85 | RXFP1 (0.63) | KDM4ERXFP1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL3813910 | 0.84 | KDM4E (0.71) | KDM4ERXFP1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4295826 | 0.84 | KDM4E (0.47) | KDM4ERXFP1ALOX15MAPK10CYP1A2 | |
| SCHEMBL4303912 | 0.84 | KDM4E (0.57) | KDM4ERXFP1ALOX15MAPK10CYP1A2 | |
| SCHEMBL4298496 | 0.84 | KDM4E (0.53) | KDM4ERXFP1CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8278345-B2 | Inhibitors of glutaminyl cyclase | PROBIODRUG AG (DE) | 2012-10-02 | — | — | US | claimed |
| US-20090269301-A1 | Novel Inhibitors of Glutaminyl Cyclase | PROBIODRUG AG (DE) | 2009-10-29 | — | — | US | claimed |
| US-8278345-B2 | Inhibitors of glutaminyl cyclase | PROBIODRUG AG (DE) | 2012-10-02 | — | — | US | disclosed |
| US-8278345-B2 | Inhibitors of glutaminyl cyclase | PROBIODRUG AG (DE) | 2012-10-02 | — | — | US | disclosed |
| US-20090269301-A1 | Novel Inhibitors of Glutaminyl Cyclase | PROBIODRUG AG (DE) | 2009-10-29 | — | — | US | disclosed |
| US-20090269301-A1 | Novel Inhibitors of Glutaminyl Cyclase | PROBIODRUG AG (DE) | 2009-10-29 | — | — | US | disclosed |
| US-20090269301-A1 | Novel Inhibitors of Glutaminyl Cyclase | PROBIODRUG AG (DE) | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090269301-A1 | Novel Inhibitors of Glutaminyl Cyclase | GLS, GLS2, GLUL | KDM4E 2532/4885RXFP1 1183/4885ALOX15 1014/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.