Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 20/20 | 0.76 |
| ▸ | JAK2 | O60674 | 17/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4302100 | 0.91 | NTRK1 (0.75) | NTRK1JAK2 | |
| SCHEMBL950685 | 0.86 | NTRK1 (1.00) | NTRK1JAK2 | |
| SCHEMBL30009510 | 0.86 | NTRK1 (1.00) | NTRK1JAK2 | |
| SCHEMBL2694949 | 0.84 | NTRK1 (1.00) | NTRK1JAK2 | |
| SCHEMBL19987903 | 0.84 | NTRK1 (0.89) | NTRK1JAK2 | |
| SCHEMBL2694945 | 0.84 | NTRK1 (1.00) | NTRK1JAK2 | |
| SCHEMBL948625 | 0.82 | NTRK1 (1.00) | NTRK1JAK2 | |
| SCHEMBL30009477 | 0.82 | NTRK1 (1.00) | NTRK1JAK2 | |
| SCHEMBL30010121 | 0.82 | NTRK1 (1.00) | NTRK1JAK2 | |
| SCHEMBL2692944 | 0.82 | NTRK1 (1.00) | NTRK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120108568-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108568-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | FRK, TXK, TNNI3K | NTRK1 8/4885JAK2 143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.