Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.68 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL5600493 | 0.98 | ADRB2 (0.66) | ADRB2HCAR2CHRNB2CHRNA4CYP3A4 | |
| SCHEMBL30485938 | 0.84 | HCAR2 (0.49) | ADRB2HCAR2CYP3A4KDM4EALDH1A1 | |
| SCHEMBL614362 | 0.82 | ADRB2 (1.00) | ADRB2CHRNB2CHRNA4CYP3A4KDM4E | |
| SCHEMBL5265906 | 0.80 | ADRB2 (0.56) | ADRB2ALDH1A1MEN1KMT2A | |
| SCHEMBL5355610 | 0.76 | ADRB2 (0.86) | ADRB2CHRNB2CHRNA4CYP3A4KDM4E | |
| SCHEMBL15771047 | 0.74 | ADRB2 (0.77) | ADRB2CHRNB2CHRNA4CYP3A4KDM4E | |
| SCHEMBL4261268 | 0.73 | ACVR1 (0.42) | ADRB2CHRNB2CHRNA4CYP3A4KDM4E | |
| SCHEMBL1939308 | 0.72 | CYP3A4 (0.63) | ADRB2HCAR2CHRNB2CHRNA4CYP3A4 | |
| SCHEMBL4008612 | 0.72 | KDM4E (0.46) | ADRB2CHRNB2CHRNA4CYP3A4KDM4E | |
| SCHEMBL16707798 | 0.70 | ADRB2 (0.68) | ADRB2CHRNB2CHRNA4CYP3A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041111-A1 | NEW PYRIDINE ANALOGUES | AstraZeneca AB (SE) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008002247-A1 | NEW PYRIDINE ANALOGUES | ASTRAZENECA AB (SE) | 2008-01-03 | — | — | WO | disclosed |