Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4296138 | 0.80 | ADRB2 (0.68) | ADRB2ALDH1A1MEN1KMT2A | |
| Piperazine SCHEMBL5600493 | 0.79 | ADRB2 (0.66) | ADRB2ALDH1A1MEN1KMT2A | |
| SCHEMBL14912336 | 0.75 | TSHR (0.46) | ALDH1A1MAPK1HTTMEN1KMT2A | |
| SCHEMBL614362 | 0.74 | ADRB2 (1.00) | ADRB2ALDH1A1MEN1KMT2A | |
| SCHEMBL3926411 | 0.74 | OPRK1 (0.56) | DYRK1AALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL3464205 | 0.73 | MAPT (0.54) | DYRK1AALDH1A1USP2MAPK1HTT | |
| SCHEMBL1521876 | 0.73 | KMT2A (0.48) | ALDH1A1MAPK1HTTMEN1KMT2A | |
| SCHEMBL13262173 | 0.72 | PDE4B (0.51) | DYRK1AALDH1A1USP2LMNAMAPK1 | |
| SCHEMBL118352 | 0.72 | CHRNB2 (0.57) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL907963 | 0.72 | P2RY12 (0.61) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836189-A1 | NOVEL PYRIDINE COMPOUNDS | AstraZeneca AB (SE) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006073361-A1 | NOVEL PYRIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2006-07-13 | — | — | WO | disclosed |