Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 19/20 | 1.00 |
| ▸ | HTR1D | P28221 | 7/20 | 1.00 |
| ▸ | DRD3 | P35462 | 7/20 | 1.00 |
| ▸ | HTR1A | P08908 | 7/20 | 1.00 |
| ▸ | DRD2 | P14416 | 7/20 | 1.00 |
| ▸ | HTR1B | P28222 | 6/20 | 1.00 |
| ▸ | HTR2B | P41595 | 4/20 | 1.00 |
| ▸ | ADRA1B | P35368 | 2/20 | 1.00 |
| ▸ | HTR2A | P28223 | 2/20 | 1.00 |
| ▸ | HTR2C | P28335 | 1/20 | 1.00 |
| ▸ | HTR6 | P50406 | 3/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.61 |
| ▸ | HTR5A | P47898 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.61 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.60 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.60 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3827869 | 1.00 | HTR7 (1.00) | HTR7HTR1DDRD3HTR1ADRD2 | |
| SCHEMBL3825498 | 0.97 | HTR7 (1.00) | HTR7HTR1DDRD3HTR1ADRD2 | |
| SCHEMBL8308503 | 0.88 | HTR7 (0.84) | HTR7HTR1DDRD3HTR1ADRD2 | |
| SCHEMBL6968795 | 0.85 | HTR7 (0.74) | HTR7HTR1DDRD3HTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL14893192 | 0.83 | HTR7 (0.72) | HTR7HTR1DDRD3HTR1ADRD2 | |
| SCHEMBL7967497 | 0.82 | HTR7 (0.74) | HTR7HTR1DDRD3HTR1ADRD2 | |
| SCHEMBL14117920 | 0.82 | HTR7 (0.77) | HTR7HTR1DDRD3HTR1ADRD2 | |
| SCHEMBL3825266 | 0.78 | HTR7 (0.69) | HTR7HTR1DDRD3HTR1ADRD2 | |
| SCHEMBL6964528 | 0.78 | HTR7 (0.69) | HTR7HTR1DDRD3HTR1ADRD2 | |
| SCHEMBL6971695 | 0.78 | HTR7 (0.68) | HTR7HTR1DDRD3HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090270455-A1 | Therapeutic agent for intestinal diseases and visceral pain | AJINOMOTO CO., INC. (JP) | 2009-10-29 | — | — | US | claimed |
| US-20050148632-A1 | Therapeutic agent for intestinal diseases and visceral pain | AJINOMOTO CO., INC. (JP) | 2005-07-07 | — | — | US | claimed |
| EP-1541172-A1 | REMEDY FOR INTESTINAL DISEASES AND VISCERAL PAIN | Ajinomoto Co., Inc. (JP) | 2005-06-15 | — | — | EP | claimed |
| US-20090270455-A1 | Therapeutic agent for intestinal diseases and visceral pain | AJINOMOTO CO., INC. (JP) | 2009-10-29 | — | — | US | disclosed |
| US-20050148632-A1 | Therapeutic agent for intestinal diseases and visceral pain | AJINOMOTO CO., INC. (JP) | 2005-07-07 | — | — | US | disclosed |
| EP-1541172-A1 | REMEDY FOR INTESTINAL DISEASES AND VISCERAL PAIN | Ajinomoto Co., Inc. (JP) | 2005-06-15 | — | — | EP | disclosed |
| EP-0912512-B1 | SULPHONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 2003-04-02 | — | — | EP | disclosed |
| US-6265408-B1 | PSYCHOLOGICAL DISORDERS; ANTIDEPRESSANT | SMITHKLINE BEECHAM PLC (GB) | 2001-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270455-A1 | Therapeutic agent for intestinal diseases and visceral pain | VIP, VIPR2, GPR17 | HTR7 6/4885HTR1D 160/4885DRD3 1845/4885 |
| US-20050148632-A1 | Therapeutic agent for intestinal diseases and visceral pain | VIP, VIPR2, GPR17 | HTR7 6/4885HTR1D 160/4885DRD3 1845/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.