Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 20/20 | 0.84 |
| ▸ | HTR1A | P08908 | 17/20 | 0.84 |
| ▸ | DRD2 | P14416 | 17/20 | 0.84 |
| ▸ | HTR1D | P28221 | 3/20 | 0.84 |
| ▸ | HTR2B | P41595 | 3/20 | 0.84 |
| ▸ | DRD3 | P35462 | 2/20 | 0.84 |
| ▸ | HTR2A | P28223 | 16/20 | 0.78 |
| ▸ | HTR1B | P28222 | 1/20 | 0.78 |
| ▸ | HTR2C | P28335 | 1/20 | 0.78 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.78 |
| ▸ | HTR6 | P50406 | 15/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3825498 | 0.91 | HTR7 (1.00) | HTR7HTR1ADRD2HTR1DHTR2B | |
| SCHEMBL7967497 | 0.89 | HTR7 (0.74) | HTR7HTR1ADRD2HTR1DHTR2B | |
| SCHEMBL3827869 | 0.88 | HTR7 (1.00) | HTR7HTR1ADRD2HTR1DHTR2B | |
| SCHEMBL4296293 | 0.88 | HTR7 (1.00) | HTR7HTR1ADRD2HTR1DHTR2B | |
| SCHEMBL3825266 | 0.86 | HTR7 (0.69) | HTR7HTR1ADRD2HTR1DHTR2B | |
| SCHEMBL6964528 | 0.86 | HTR7 (0.69) | HTR7HTR1ADRD2HTR1DHTR2B | |
| SCHEMBL6971695 | 0.85 | HTR7 (0.68) | HTR7HTR1ADRD2HTR1DHTR2B | |
| SCHEMBL6920929 | 0.83 | HTR7 (0.65) | HTR7HTR1ADRD2HTR1DHTR2B | |
| SCHEMBL8177201 | 0.81 | HTR7 (0.64) | HTR7HTR1ADRD2HTR1DHTR2B | |
| SCHEMBL699980 | 0.81 | HTR7 (0.63) | HTR7HTR1ADRD2HTR1DHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912512-A1 | SULPHONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 1999-05-06 | — | — | EP | claimed |
| WO-1997048681-A1 | SULPHONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 1997-12-24 | — | — | WO | claimed |
| EP-0912512-A1 | SULPHONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997048681-A1 | SULPHONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 1997-12-24 | — | — | WO | disclosed |