Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | PTPRF | P10586 | 1/20 | 0.51 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 3/20 | 0.49 |
| ▸ | CA1 | P00915 | 3/20 | 0.49 |
| ▸ | IDO1 | P14902 | 3/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | MMP14 | P50281 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1829766 | 0.77 | LOXL2 (0.61) | LOXL2CHRM2PTPRFPTPN2PTPN1 | |
| SCHEMBL628651 | 0.77 | CHRM2 (0.72) | LOXL2CHRM2PTPRFPTPN2PTPN1 | |
| Hydrochloric Acid SCHEMBL28365077 | 0.76 | LOXL2 (0.59) | LOXL2CHRM2PTPRFPTPN2PTPN1 | |
| SCHEMBL2012871 | 0.74 | HSD17B10 (0.49) | ALDH1A1POLB | |
| SCHEMBL1262320 | 0.73 | CHRM2 (0.58) | LOXL2CHRM2PTPRFPTPN2PTPN1 | |
| SCHEMBL5356054 | 0.73 | CHRM2 (0.58) | LOXL2CHRM2PTPRFPTPN2PTPN1 | |
| SCHEMBL6246420 | 0.73 | CHRM2 (0.58) | LOXL2CHRM2PTPRFPTPN2PTPN1 | |
| SCHEMBL1938300 | 0.73 | CHRM2 (0.58) | LOXL2CHRM2PTPRFPTPN2PTPN1 | |
| SCHEMBL11597593 | 0.73 | CHRM2 (0.79) | LOXL2CHRM2PTPRFPTPN2PTPN1 | |
| SCHEMBL11415667 | 0.72 | ALDH1A1 (0.53) | LOXL2CA2CA1CA12CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090208460-A1 | Mutant Herpes Simplex Viruses Comprising Nucleic Acid Encoding A Nitroreductase | CRUSADE LABORATORIES LIMITED (GB) | 2009-08-20 | — | — | US | disclosed |
| EP-1685254-B1 | ONCOLYTIC HERPES SIMPLEX VIRUS ENCODING A HETEROLOGOUS NITROREDUCTASE | CRUSADE LAB LTD (GB) | 2009-06-10 | — | — | EP | disclosed |
| US-7498161-B2 | Mutant herpes simplex viruses comprising nucleic acid encoding a nitroreductase | CRUSADE LABORATORIES LIMITED (GB) | 2009-03-03 | — | — | US | disclosed |
| US-20070098689-A1 | Mutant viruses | VIRTTU BIOLOGICS LIMITED | 2007-05-03 | — | — | US | disclosed |
| WO-2005049845-A9 | ONCOLYTIC HERPES SIMPLEX VIRUS ENCODING A HETEROLOGOUS NITROREDUCTASE | CRUSADE LAB LTD (GB) | 2006-08-17 | — | — | WO | disclosed |
| EP-1685254-A2 | ONCOLYTIC HERPES SIMPLEX VIRUS ENCODING A HETEROLOGOUS NITROREDUCTASE | Crusade Laboratories Limited (GB) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005049845-A2 | ONCOLYTIC HERPES SIMPLEX VIRUS ENCODING A HETEROLOGOUS NITROREDUCTASE | CRUSADE LABORATORIES LIMITED (GB) | 2005-06-02 | — | — | WO | disclosed |