Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | DHFR | P00374 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.49 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.47 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.47 |
| ▸ | TUBB | P07437 | 3/20 | 0.47 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.47 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.47 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.47 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.47 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.47 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.47 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.47 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.47 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.47 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1317516 | 0.81 | SMN1; SMN2 (0.61) | SMN1; SMN2DHFRHSP90AA1HSP90AB1KMT2A | |
| SCHEMBL28736302 | 0.79 | SMN1; SMN2 (0.71) | SMN1; SMN2POLBGAAMAPTDHFR | |
| SCHEMBL29610081 | 0.79 | SMN1; SMN2 (0.71) | SMN1; SMN2POLBGAAMAPTDHFR | |
| SCHEMBL6265152 | 0.77 | KMT2A (0.55) | SMN1; SMN2POLBGAAMAPTHSP90AA1 | |
| SCHEMBL12488038 | 0.76 | TUBB4A (0.46) | SMN1; SMN2DHFRTUBB3TUBB4ATUBB | |
| SCHEMBL4300255 | 0.75 | MEN1 (0.53) | SMN1; SMN2MAPTTUBB3TUBB4ATUBB | |
| SCHEMBL2724359 | 0.72 | SMN1; SMN2 (0.48) | SMN1; SMN2MAPTDHFRHSP90AA1HSP90AB1 | |
| SCHEMBL1644753 | 0.72 | DYRK1A (0.71) | SMN1; SMN2POLBGAAMAPTHSP90AA1 | |
| SCHEMBL6345046 | 0.72 | EGFR (0.41) | SMN1; SMN2POLBGAAMAPTDHFR | |
| SCHEMBL1320790 | 0.71 | KMT2A (0.63) | SMN1; SMN2MAPTHSP90AA1HSP90AB1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090280133-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF | MYRIAD GENETICS, INCORPORATED (US) | 2009-11-12 | — | — | US | claimed |
| US-20090280133-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF | MYRIAD GENETICS, INCORPORATED (US) | 2009-11-12 | — | — | US | disclosed |
| US-20090280133-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF | MYRIAD GENETICS, INCORPORATED (US) | 2009-11-12 | — | — | US | disclosed |
| US-20090280133-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF | MYRIAD GENETICS, INCORPORATED (US) | 2009-11-12 | — | — | US | disclosed |
| WO-2008061112-A9 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF | MYRIAD GENETICS INC (US) | 2008-09-18 | — | — | WO | disclosed |
| WO-2008061112-A2 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF | MYRIAD GENETICS, INC. (US) | 2008-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090280133-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF | MKI67, CCNI, CCNA1 | SMN1; SMN2 1498/4885POLB 1329/4885GAA 120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.