Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28736302 | 0.88 | SMN1; SMN2 (0.71) | KMT2AKDM4ESMN1; SMN2MAPTPOLB | |
| SCHEMBL29610081 | 0.88 | SMN1; SMN2 (0.71) | KMT2AKDM4ESMN1; SMN2MAPTPOLB | |
| SCHEMBL114531 | 0.84 | PIK3CA (0.49) | KMT2AKDM4ESMN1; SMN2MAPTNPSR1 | |
| SCHEMBL24460959 | 0.84 | LMNA (0.43) | KMT2AKDM4ESMN1; SMN2MAPTPOLB | |
| SCHEMBL24272825 | 0.82 | TSPO (0.44) | KMT2AKDM4ESMN1; SMN2MAPTHSP90AA1 | |
| SCHEMBL6265329 | 0.81 | SMN1; SMN2 (0.73) | KMT2AKDM4ESMN1; SMN2HSP90AB1HSP90AA1 | |
| SCHEMBL30759080 | 0.81 | PIK3CD (0.41) | KMT2ASMN1; SMN2MAPTGAAHSP90AA1 | |
| SCHEMBL14806844 | 0.79 | PIK3CA (0.45) | KMT2AKDM4ESMN1; SMN2MAPTHSP90AA1 | |
| SCHEMBL28865948 | 0.78 | LMNA (0.43) | KMT2AMAPTHSP90AA1ALDH1A1CYP2D6 | |
| SCHEMBL21379903 | 0.78 | PIK3CA (0.48) | KMT2ASMN1; SMN2MAPTPOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066266-B1 | CYCLIN DEPENDENT KINASE INHIBITORS | CANCER REC TECH LTD (GB) | 2005-11-09 | — | — | EP | disclosed |
| US-6677345-B1 | PYRMIDINE DERIVATIVE ANTITUMOR AND ANTIPROLIFERATIVE AGENTS | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2004-01-13 | — | — | US | disclosed |