SCHEMBL4298015

SCHEMBL4298015

C[C@]12CC[C@H]3[C@@H](CCC4=CCCC[C@@]43C)[C@@H]1CC[C@@H]2CCO

nearest known ligand 0.69

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 19/20 0.69
SHBG P04278 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9782727 0.91 CYP19A1 (0.72) CYP19A1SHBG
SCHEMBL9782731 0.91 CYP19A1 (0.72) CYP19A1SHBG
SCHEMBL28278507 0.89 CYP19A1 (0.67) CYP19A1
SCHEMBL7611386 0.88 CYP19A1 (0.69) CYP19A1SHBG
SCHEMBL141797 0.87 CYP19A1 (0.70) CYP19A1
SCHEMBL194995 0.87 CYP19A1 (0.70) CYP19A1
SCHEMBL3663524 0.87 CYP19A1 (0.64) CYP19A1
SCHEMBL1651377 0.87 CYP19A1 (0.64) CYP19A1
SCHEMBL11562256 0.86 CYP19A1 (0.74) CYP19A1
SCHEMBL8375052 0.86 CYP19A1 (0.63) CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025096087-A1 TREATMENT OF MYELOID CELL DYSFUNCTION WITH MEMBRANE SPANNING 4-DOMAINS A6A (MS4A6A) INHIBITORS REGENERON PHARMACEUTICALS, INC. (US) 2025-05-08 WO disclosed
US-20250134920-A1 Treatment Of Myeloid Cell Dysfunction With Membrane Spanning 4-Domains A6A (MS4A6A) Inhibitors REGENERON PHARMACEUTICALS, INC. 2025-05-01 US disclosed
US-20130281418-A1 Use of hydroxypregnenolone derivatives for enhancing health and physical performance MARCHEWITZ ERIC D (US) 2013-10-24 US disclosed
US-20130123175-A1 Compounds for Delivery of Therapeutic And Imaging Moieties to Nerve Cells HILL G CRAIG (US) 2013-05-16 US disclosed
US-8232251-B2 Compounds for delivery of therapeutic and imaging moieties to nerve cells MANZANITA PHARMACEUTICALS, INC. (US) 2012-07-31 US disclosed
US-20090286732-A1 COMPOUNDS FOR DELIVERY OF THERAPEUTIC AND IMAGING MOIETIES TO NERVE CELLS MANZANITA PHARMACEUTICALS, INC. 2009-11-19 US disclosed
EP-1781268-A1 TREATMENT OF MYOCARDIAL INFARCTION WITH 11HSD1 INHIBITORS THE UNIVERSITY OF EDINBURGH (GB) 2007-05-09 EP disclosed
WO-2006021744-A1 TREATMENT OF MYOCARDIAL INFARCTION WITH 11HSD1 INHIBITORS THE UNIVERSITY OF EDINBURGH (GB) 2006-03-02 WO disclosed
US-20040120891-A1 Compounds for intracellular delivery of therapeutic moieties to nerve cells ASILOMAR PHARMACEUTICALS, INC. 2004-06-24 US disclosed
EP-0141684-B1 HYDROCORTISONE-17-CARBOXYLIC-ACID ESTER 21-THIOCARBOXYLYC-ACID ESTERS, THEIR PREPARATION AND THEIR USE AS MEDICINES JOUVEINAL S.A. (FR) 1987-09-30 EP disclosed
EP-0141684-A1 Hydrocortisone-17-carboxylic-acid ester 21-thiocarboxylyc-acid esters, their preparation and their use as medicines JOUVEINAL S.A. (FR) 1985-05-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040120891-A1 Compounds for intracellular delivery of therapeutic moieties to nerve cells CLTB, NMBR, OPRL1 CYP19A1 4819/4885SHBG 2686/4885
US-20090286732-A1 COMPOUNDS FOR DELIVERY OF THERAPEUTIC AND IMAGING MOIETIES TO NERVE CELLS CLTB, NMBR, L1CAM CYP19A1 4413/4885SHBG 1513/4885
US-20130123175-A1 Compounds for Delivery of Therapeutic And Imaging Moieties to Nerve Cells CLTB, NMBR, L1CAM CYP19A1 4413/4885SHBG 1513/4885
US-20130281418-A1 Use of hydroxypregnenolone derivatives for enhancing health and physical performance HSD17B11, CYP19A1, HSD17B1 CYP19A1 2/4885SHBG 13/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.