Sugi Predict

Sugi Predict / Compounds / SCHEMBL429823

SCHEMBL429823

SCHEMBL429823

CC1(C)CC(Nc2nc(Nc3cc(N)c(C4CC4)cc3F)ncc2F)CC(C)(C)N1

nearest known ligand 0.40

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ CSNK2A2 P19784 2/20 0.40
▸ CSNK2A1 P68400 2/20 0.40
▸ PRKCQ Q04759 1/20 0.37
▸ IGF1R P08069 2/20 0.36
▸ AURKA O14965 1/20 0.35
▸ AURKB Q96GD4 1/20 0.35
▸ ULK1 O75385 2/20 0.35
▸ SYK P43405 2/20 0.35
▸ NTRK1 P04629 1/20 0.34
▸ EGFR P00533 4/20 0.33
▸ ALK Q9UM73 2/20 0.33
▸ BTK Q06187 2/20 0.33
▸ JAK2 O60674 1/20 0.33
▸ ITK Q08881 2/20 0.32
▸ KMT2A Q03164 1/20 0.32
▸ CDK7 P50613 1/20 0.32
▸ CDK9 P50750 1/20 0.32
▸ ULK2 Q8IYT8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20246982 0.82 CSNK2A2 (0.37) CSNK2A2CSNK2A1PRKCQIGF1RAURKA
SCHEMBL10199432 0.82 CSNK2A2 (0.38) CSNK2A2CSNK2A1PRKCQIGF1RAURKA
SCHEMBL429225 0.82 CSNK2A2 (0.38) CSNK2A2CSNK2A1PRKCQIGF1RAURKA
SCHEMBL431651 0.81 PRKCQ (0.42) CSNK2A2CSNK2A1PRKCQIGF1RAURKA
SCHEMBL430980 0.81 PRKCQ (0.49) CSNK2A2CSNK2A1PRKCQIGF1RAURKA
SCHEMBL20246950 0.81 CSNK2A2 (0.36) CSNK2A2CSNK2A1PRKCQIGF1RAURKA
SCHEMBL1942477 0.80 PRKCQ (0.37) CSNK2A2CSNK2A1PRKCQIGF1RAURKA
SCHEMBL1945441 0.80 CSNK2A2 (0.37) CSNK2A2CSNK2A1PRKCQIGF1RAURKA
SCHEMBL20247178 0.80 CSNK2A2 (0.36) CSNK2A2CSNK2A1PRKCQIGF1RAURKA
SCHEMBL431285 0.79 PRKCQ (0.41) CSNK2A2CSNK2A1PRKCQIGF1RAURKA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2595982-B1 PROTEIN KINASE C INHIBITORS AND USES THEREOF RIGEL PHARMACEUTICALS INC (US) 2018-06-13 — — EP disclosed
US-9181222-B2 Protein kinase C inhibitors and uses thereof RIGEL PHARMACEUTICALS, INC. (US) 2015-11-10 — — US disclosed
US-20140329842-A1 Protein Kinase C Inhibitors and Uses Thereof RIGEL PHARMACEUTICALS, INC. (US) 2014-11-06 — — US disclosed
US-8710223-B2 Protein kinase C inhibitors and uses thereof RIGEL PHARMACEUTICALS, INC. (US) 2014-04-29 — — US disclosed
EP-2595982-A1 PROTEIN KINASE C INHIBITORS AND USES THEREOF Rigel Pharmaceuticals, Inc. (US) 2013-05-29 — — EP disclosed
WO-2012012619-A1 PROTEIN KINASE C INHIBITORS AND USES THEREOF RIGEL PHARMACEUTICALS, INC. (US) 2012-01-26 — — WO disclosed
US-20120022092-A1 PROTEIN KINASE C INHIBITORS AND USES THEREOF MIDCAP FINANCIAL TRUST 2012-01-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140329842-A1 Protein Kinase C Inhibitors and Uses Thereof PRKCH, PRKCA, PRKCB CSNK2A2 158/4885CSNK2A1 163/4885PRKCQ 5/4885
US-20120022092-A1 PROTEIN KINASE C INHIBITORS AND USES THEREOF PRKCH, PRKCA, PRKCB CSNK2A2 158/4885CSNK2A1 163/4885PRKCQ 5/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.