Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Glutamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 4/20 | 0.64 |
| ▸ | SLC1A2 | P43004 | 4/20 | 0.64 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | GRM8 | O00222 | 2/20 | 0.64 |
| ▸ | GRM6 | O15303 | 2/20 | 0.64 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.64 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.64 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.64 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.64 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.64 |
| ▸ | GSR | P00390 | 1/20 | 0.64 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.64 |
| ▸ | GRM5 | P41594 | 1/20 | 0.64 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.64 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.64 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.64 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.64 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.64 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutamic Acid SCHEMBL8578629 | 0.97 | SLC1A3 (0.60) | SLC1A3SLC1A2SLC1A1CYP1A2GRM8 | |
| D-Glutamate SCHEMBL8578626 | 0.97 | SLC1A3 (0.60) | SLC1A3SLC1A2SLC1A1CYP1A2GRM8 | |
| Glutamic Acid SCHEMBL1126187 | 0.94 | SLC1A3 (0.72) | SLC1A3SLC1A2SLC1A1CYP1A2GRM8 | |
| D-Glutamate SCHEMBL9176409 | 0.94 | SLC1A3 (0.72) | SLC1A3SLC1A2SLC1A1CYP1A2GRM8 | |
| Glutamic Acid SCHEMBL6130437 | 0.94 | SLC1A3 (0.72) | SLC1A3SLC1A2SLC1A1CYP1A2GRM8 | |
| Glutamic Acid SCHEMBL24357 | 0.94 | SLC1A3 (0.72) | SLC1A3SLC1A2SLC1A1CYP1A2GRM8 | |
| Glutamic Acid SCHEMBL5614072 | 0.94 | SLC1A3 (0.72) | SLC1A3SLC1A2SLC1A1CYP1A2GRM8 | |
| D-Glutamate SCHEMBL3512077 | 0.94 | SLC1A3 (0.72) | SLC1A3SLC1A2SLC1A1CYP1A2GRM8 | |
| D-Glutamate SCHEMBL19876607 | 0.91 | SLC1A3 (0.67) | SLC1A3SLC1A2SLC1A1CYP1A2GRM8 | |
| Glutamic Acid SCHEMBL1365479 | 0.91 | SLC1A3 (0.67) | SLC1A3SLC1A2SLC1A1CYP1A2GRM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2797616-B1 | CELL-PENETRATING PEPTIDES | UNIV SORBONNE (FR) | 2019-07-31 | — | — | EP | claimed |
| EP-3080296-B1 | A METHOD OF PREDICTING A RESPONSE TO AN ANTI-TUMOR TREATMENT | UNIV SORBONNE (FR) | 2018-09-19 | — | — | EP | claimed |
| CN-104271147-B | Cell-penetrating peptide | 巴黎第六大学 | 2018-01-12 | — | — | CN | claimed |
| US-20160312293-A1 | A METHOD OF PREDICTING A RESPONSE TO AN ANTI-TUMOR TREATMENT | SORBONNE UNIVERSITE (FR) | 2016-10-27 | — | — | US | claimed |
| US-20160257713-A1 | CELL-PENETRATING PEPTIDES | SORBONNE UNIVERSITE (FR) | 2016-09-08 | — | — | US | claimed |
| EP-2881472-A1 | A method of predicting a response to an anti-tumor treatment | Université Pierre et Marie Curie (Paris 6) (FR) | 2015-06-10 | — | — | EP | claimed |
| US-20150030699-A1 | ANTI-TUMOR ADJUVANT THERAPY | SORBONNE UNIVERSITE (FR) | 2015-01-29 | — | — | US | claimed |
| US-20140364376-A1 | CELL-PENETRATING PEPTIDES | SORBONNE UNIVERSITE (FR) | 2014-12-11 | — | — | US | claimed |
| EP-2797617-A1 | ANTI-TUMOR ADJUVANT THERAPY | Université Pierre et Marie Curie (Paris 6) (FR) | 2014-11-05 | — | — | EP | claimed |
| EP-2797616-A1 | CELL-PENETRATING PEPTIDES | Université Pierre et Marie Curie (Paris 6) (FR) | 2014-11-05 | — | — | EP | claimed |
| WO-2013098339-A1 | ANTI-TUMOR ADJUVANT THERAPY | UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) (FR) | 2013-07-04 | — | — | WO | claimed |
| WO-2013098337-A1 | CELL-PENETRATING PEPTIDES | UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) (FR) | 2013-07-04 | — | — | WO | claimed |
| US-20120021999-A1 | PRO-APOPTOTIC PEPTIDES | REBOLLO GARCIA ANGELITA (FR) | 2012-01-26 | — | — | US | claimed |
| EP-2236603-A1 | PRO-APOPTOTIC PEPTIDES | UNIVERSITE PIERRE ET MARIE CURIE (FR) | 2010-10-06 | — | — | EP | claimed |
| US-10947276-B2 | Cell penetrating peptides with improved internalization properties | Sorbonne Université (FR) | 2021-03-16 | — | — | US | disclosed |
| US-10508310-B2 | Method of predicting a response to an anti-tumor treatment | SORBONNE UNIVERSITE (FR) | 2019-12-17 | — | — | US | disclosed |
| US-20190337985-A1 | CELL PENETRATING PEPTIDES WITH IMPROVED INTERNALIZATION PROPERTIES | PEP-THERAPY (FR) | 2019-11-07 | — | — | US | disclosed |
| US-20120021999-A1 | PRO-APOPTOTIC PEPTIDES | REBOLLO GARCIA ANGELITA (FR) | 2012-01-26 | — | — | US | disclosed |
| WO-2010112471-A1 | PRO-APOPTOTIC PEPTIDES | UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) (FR) | 2010-10-07 | — | — | WO | disclosed |
| EP-2236603-A1 | PRO-APOPTOTIC PEPTIDES | UNIVERSITE PIERRE ET MARIE CURIE (FR) | 2010-10-06 | — | — | EP | disclosed |