Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UBE2M | P61081 | 5/20 | 0.40 |
| ▸ | DCUN1D1 | Q96GG9 | 5/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | F13A1 | P00488 | 1/20 | 0.35 |
| ▸ | TGM2 | P21980 | 1/20 | 0.35 |
| ▸ | TGM1 | P22735 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | QPCT | Q16769 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL400383 | 0.84 | KMT2A (0.45) | LMNAMAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL399090 | 0.74 | HTR1A (0.50) | LMNAMAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3204846 | 0.74 | MEN1 (0.47) | LMNASIGMAR1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL402430 | 0.73 | HTR1A (0.42) | MAPTKMT2AMEN1CYP1A2 | |
| SCHEMBL400040 | 0.72 | MEN1 (0.47) | LMNAMAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL400961 | 0.72 | MEN1 (0.47) | LMNAMAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL23573834 | 0.70 | PIK3CA (0.45) | SIGMAR1MAPTQPCTALDH1A1RAB9A | |
| SCHEMBL402096 | 0.66 | CYP1A2 (0.46) | LMNAALDH1A1CYP1A2 | |
| SCHEMBL4293362 | 0.66 | HTR1A (0.39) | UBE2MDCUN1D1F13A1TGM2TGM1 | |
| SCHEMBL401535 | 0.65 | HTR1A (0.50) | SIGMAR1MAPTSMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765327-A4 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS INC (US) | 2009-06-17 | — | — | EP | disclosed |
| EP-1765327-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | Cytokinetics, Inc. (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006009726-A2 | SUBSTITUTED UREA DERIVATIVES FOR TREATING CARDIAC DISEASES | CYTOKINETICS, INC. (US) | 2006-01-26 | — | — | WO | disclosed |