Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.38 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | TOP1 | P11387 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4005617 | 0.91 | ITGB1 (0.36) | POLBITGB1ITGA4ITGB7 | |
| SCHEMBL4010758 | 0.89 | ALDH1A1 (0.37) | KMT2AALDH1A1POLBITGB1ITGA4 | |
| SCHEMBL4000706 | 0.86 | KMT2A (0.38) | KMT2APOLBITGB1ITGA4ITGB7 | |
| SCHEMBL4005139 | 0.85 | ABCB1 (0.38) | KMT2AALDH1A1ITGB1ITGA4ITGB7 | |
| SCHEMBL4009205 | 0.85 | ITGB1 (0.38) | ITGB1ITGA4ITGB7 | |
| SCHEMBL4002243 | 0.84 | ALDH1A1 (0.37) | KMT2AALDH1A1POLBCNR2MEN1 | |
| SCHEMBL4010548 | 0.83 | HSD11B1 (0.38) | ITGB1ITGA4ITGB7 | |
| SCHEMBL4006854 | 0.83 | ALDH1A1 (0.37) | ALDH1A1TOP1 | |
| SCHEMBL4006907 | 0.83 | MEN1 (0.41) | KMT2AALDH1A1FAAHCNR2MEN1 | |
| SCHEMBL4010793 | 0.81 | GRM5 (0.42) | KMT2AALDH1A1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778229-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-06-17 | — | — | EP | disclosed |
| EP-1778229-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006020598-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-23 | — | — | WO | disclosed |