SCHEMBL4300716

SCHEMBL4300716

C[C@@H](OC1CCCCO1)C(=O)O

nearest known ligand 0.37

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
SLC6A3 Q01959 4/20 0.36
NPSR1 Q6W5P4 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
HPGD P15428 2/20 0.35
TSHR P16473 1/20 0.35
ALDH1A1 P00352 1/20 0.33
PTGER4 P35408 1/20 0.33
PTGDR2 Q9Y5Y4 2/20 0.32
PTGDR Q13258 1/20 0.32
GAA P10253 1/20 0.31
ACE P12821 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9044354 1.00 MEN1 (0.37) MEN1KMT2ASLC6A3NPSR1SMN1; SMN2
SCHEMBL4300719 1.00 MEN1 (0.37) MEN1KMT2ASLC6A3NPSR1SMN1; SMN2
SCHEMBL4300724 1.00 MEN1 (0.37) MEN1KMT2ASLC6A3NPSR1SMN1; SMN2
SCHEMBL9213202 1.00 MEN1 (0.37) MEN1KMT2ASLC6A3NPSR1SMN1; SMN2
SCHEMBL5686664 0.91 SMN1; SMN2 (0.40) MEN1KMT2ASLC6A3NPSR1SMN1; SMN2
SCHEMBL27328368 0.87 MEN1 (0.35) MEN1KMT2ASLC6A3NPSR1HPGD
SCHEMBL17265224 0.86 MEN1 (0.34) MEN1KMT2ASLC6A3NPSR1HPGD
SCHEMBL17267071 0.84 MEN1 (0.33) MEN1KMT2ASLC6A3NPSR1HPGD
SCHEMBL29397857 0.84 EPHX1 (0.33) MEN1KMT2ASLC6A3NPSR1HPGD
SCHEMBL18600852 0.83 MEN1 (0.35) MEN1KMT2ASLC6A3NPSR1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240239778-A1 GRISEOFULVIN COMPOUND AND PHARMACEUTICAL USE THEREOF DAIICHI SANKYO COMPANY, LIMITED (JP) 2024-07-18 US disclosed
US-11993593-B2 Griseofulvin compound and pharmaceutical use thereof DAIICHI SANKYO COMPANY, LIMITED (JP) 2024-05-28 US disclosed
US-20240150309-A1 GRISEOFULVIN COMPOUND DAIICHI SANKYO COMPANY, LIMITED (JP) 2024-05-09 US disclosed
CN-117897384-A CDK2 inhibitors 缆图药品公司 2024-04-16 CN disclosed
EP-4308570-A1 MACROCYCLIC LRRK2 KINASE INHIBITORS Les Laboratoires Servier (FR) 2024-01-24 EP disclosed
CN-117425661-A Macrocyclic LRRK2 kinase inhibitors 法国施维雅药厂 2024-01-19 CN disclosed
US-11834427-B2 Griseofulvin compound DAIICHI SANKYO COMPANY, LIMITED (JP) 2023-12-05 US disclosed
US-20230136988-A1 GRISEOFULVIN COMPOUND DAIICHI SANKYO COMPANY, LIMITED (JP) 2023-05-04 US disclosed
US-20220411416-A1 GRISEOFULVIN COMPOUND AND PHARMACEUTICAL USE THEREOF DAIICHI SANKYO COMPANY, LIMITED (JP) 2022-12-29 US disclosed
EP-4032883-A1 GRISEOFULVIN COMPOUND Daiichi Sankyo Company, Limited (JP) 2022-07-27 EP disclosed
US-20190092741-A1 GRISEOFULVIN COMPOUND DAIICHI SANKYO COMPANY, LIMITED (JP) 2019-03-28 US disclosed
EP-3438103-A1 GRISEOFULVIN COMPOUND DAIICHI SANKYO COMPANY, LIMITED (JP) 2019-02-06 EP disclosed
US-7582781-B2 epoxidation to produce 1,2-Epoxy-2-(2,4-difluorophenyl)butan-3-ol intermediate for pharmaceutical drugs, a triazole antifungal agent KANEKA CORPORATION (JP) 2009-09-01 US disclosed
US-20060155136-A1 Optically active halohydrin derivative and process for producing optically active epoxy alcohol derivative from the same KANEKA CORPORATION (JP) 2006-07-13 US disclosed
EP-1647551-A1 OPTICALLY ACTIVE HALOHYDRIN DERIVATIVE AND PROCESS FOR PRODUCING OPTICALLY ACTIVE EPOXY ALCOHOL DERIVATIVE FROM THE SAME KANEKA CORPORATION (JP) 2006-04-19 EP disclosed
US-6720463-B1 REDUCING AN ALKYLHYDROXYESTER WITH EASY TO HANDLE SODIUM BOROHYDRIDE; MAINTAINING OPTICAL ACTIVITY IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 2004-04-13 US disclosed
EP-1146032-A1 PROCESS FOR THE PRODUCTION OF ALKANEDIOL DERIVATIVES IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) 2001-10-17 EP disclosed
EP-0728752-A1 Triazole compounds, their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-08-28 EP disclosed
US-5405861-A Fungicides TAKEDA CHEMICAL INDUSTRIES, CO., LTD. (JP) 1995-04-11 US disclosed
EP-0421210-A2 Triazole compounds, their production and use Takeda Chemical Industries, Ltd. (JP) 1991-04-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060155136-A1 Optically active halohydrin derivative and process for producing optically active epoxy alcohol derivative from the same TALDO1, CYP51A1, ERG28 MEN1 3817/4885KMT2A 2433/4885SLC6A3 2434/4885
US-11834427-B2 Griseofulvin compound PTGS1, CYP11B1, GRIA1 MEN1 2215/4885KMT2A 3933/4885SLC6A3 2434/4885
US-20240239778-A1 GRISEOFULVIN COMPOUND AND PHARMACEUTICAL USE THEREOF ACBD3, NR3C1, GRN MEN1 654/4885KMT2A 4235/4885SLC6A3 1728/4885
US-20240150309-A1 GRISEOFULVIN COMPOUND PTGS1, CYP11B1, GRIA1 MEN1 2215/4885KMT2A 3933/4885SLC6A3 2434/4885
US-20230136988-A1 GRISEOFULVIN COMPOUND PTGS1, CYP11B1, GRIA1 MEN1 2215/4885KMT2A 3933/4885SLC6A3 2434/4885
US-20190092741-A1 GRISEOFULVIN COMPOUND PTGS1, CYP11B1, GRIA1 MEN1 2215/4885KMT2A 3933/4885SLC6A3 2434/4885
US-11993593-B2 Griseofulvin compound and pharmaceutical use thereof ACBD3, GRN, C1S MEN1 632/4885KMT2A 4213/4885SLC6A3 1713/4885
US-20220411416-A1 GRISEOFULVIN COMPOUND AND PHARMACEUTICAL USE THEREOF ACBD3, NR3C1, GRN MEN1 654/4885KMT2A 4235/4885SLC6A3 1728/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.