Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | TLR4 | O00206 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PRNP | P04156 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4300918 | 0.84 | KDR (0.44) | KDRTLR4RETPDGFRBKIT | |
| SCHEMBL2434609 | 0.78 | MEN1 (0.52) | MEN1KMT2ASMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL273408 | 0.76 | KDR (0.63) | MEN1KMT2ASMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL261543 | 0.73 | PRKAG1 (0.45) | KMT2ASMN1; SMN2RAB9AALDH1A1LMNA | |
| SCHEMBL492471 | 0.71 | MCL1 (0.50) | MEN1KMT2ASMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL1324260 | 0.70 | SMN1; SMN2 (0.52) | MEN1KMT2ASMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL1573241 | 0.70 | DYRK1A (0.45) | SMN1; SMN2RAB9ALMNANPC1GAA | |
| SCHEMBL1572956 | 0.70 | MAPT (0.48) | MEN1KMT2ASMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL16441869 | 0.69 | MEN1 (0.75) | MEN1KMT2ASMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL492395 | 0.66 | POLB (0.37) | ALDH1A1POLBMAPTTSHRDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090030009-A1 | Heterobicyclic Carboxamides as Inhibitors for Kinases | NOVARTIS AG (CH) | 2009-01-29 | — | — | US | disclosed |
| EP-1996578-A1 | HETEROBICYCLIC CARBOXAMIDES AS INHIBITORS FOR KINASES | Novartis AG (CH) | 2008-12-03 | — | — | EP | disclosed |
| WO-2008009487-A1 | HETEROBICYCLIC CARBOXAMIDES AS INHIBITORS FOR KINASES | NOVARTIS AG (CH) | 2008-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090030009-A1 | Heterobicyclic Carboxamides as Inhibitors for Kinases | PHKG1, MAP3K20, CDK2 | MEN1 2277/4885KMT2A 887/4885SMN1; SMN2 4023/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.