Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.63 |
| ▸ | CA2 | P00918 | 4/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | ESR1 | P03372 | 2/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | PARP4 | Q9UKK3 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.48 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.48 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.48 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | BLM | P54132 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydroquinone SCHEMBL8674228 | 0.90 | PARP10 (0.74) | PARP10CA2CA1MAPTESR1 | |
| SCHEMBL28823636 | 0.90 | PARP10 (0.74) | PARP10CA2CA1MAPTESR1 | |
| SCHEMBL162830 | 0.90 | PARP10 (0.74) | PARP10CA2CA1MAPTESR1 | |
| SCHEMBL25338154 | 0.88 | PARP10 (0.65) | PARP10CA2CA1MAPTESR1 | |
| SCHEMBL28831945 | 0.87 | PARP10 (0.71) | PARP10CA2CA1MAPTESR1 | |
| Ammonia Solution, Strong SCHEMBL28805645 | 0.87 | PARP10 (0.71) | PARP10CA2CA1MAPTESR1 | |
| Methane SCHEMBL28048015 | 0.87 | PARP10 (0.71) | PARP10CA2CA1MAPTESR1 | |
| Hydrochloric Acid SCHEMBL3139339 | 0.87 | PARP10 (0.71) | PARP10CA2CA1MAPTESR1 | |
| SCHEMBL1791123 | 0.83 | PARP10 (0.65) | PARP10CA2CA1MAPTESR1 | |
| Benzamide SCHEMBL10890603 | 0.81 | MAPT (0.76) | PARP10CA2CA1MAPTESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2073803-A1 | PHARMACEUTICAL COMBINATIONS | Astex Therapeutics Limited (GB) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008044041-A1 | PHARMACEUTICAL COMBINATIONS | ASTEX THERAPEUTICS LIMITED (GB) | 2008-04-17 | — | — | WO | disclosed |