Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.57 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.57 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.57 |
| ▸ | CTSK | P43235 | 5/20 | 0.50 |
| ▸ | CTSS | P25774 | 2/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4301545 | 1.00 | HDAC1 (0.59) | HDAC1HDAC4HDAC8HDAC3HDAC7 | |
| SCHEMBL4166176 | 0.89 | HDAC4 (0.57) | HDAC1HDAC4HDAC8HDAC3HDAC7 | |
| SCHEMBL4312734 | 0.87 | HDAC1 (0.59) | HDAC1HDAC4HDAC8HDAC3HDAC7 | |
| SCHEMBL4312731 | 0.87 | HDAC4 (0.54) | HDAC1HDAC4HDAC8HDAC3HDAC7 | |
| SCHEMBL30861281 | 0.86 | HDAC4 (0.65) | HDAC1HDAC4HDAC8HDAC3HDAC7 | |
| SCHEMBL11036298 | 0.86 | HDAC4 (0.53) | HDAC1HDAC4HDAC8HDAC3HDAC7 | |
| SCHEMBL29481024 | 0.80 | SMN1; SMN2 (0.51) | HDAC1HDAC4HDAC8HDAC3HDAC7 | |
| SCHEMBL27613652 | 0.79 | HDAC4 (0.61) | HDAC1HDAC4HDAC8HDAC3HDAC7 | |
| SCHEMBL21715586 | 0.77 | GABRB1 (0.48) | CTSKCTSSCTSBGABRB1GABRB2 | |
| SCHEMBL6715868 | 0.77 | CTSS (0.57) | HDAC8CTSKCTSSCTSBGABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054448-A1 | Amino Acid Derivatives as Histone Deacetylase (HDAC) Inhibitors | JONES PHILIP | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054448-A1 | Amino Acid Derivatives as Histone Deacetylase (HDAC) Inhibitors | HDAC5, HDAC1, HDAC11 | HDAC1 2/4885HDAC4 4/4885HDAC8 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.