Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY1 | P47900 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 5/20 | 0.39 |
| ▸ | FPR1 | P21462 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3200068 | 0.89 | RORC (0.47) | RORCDHODHCCR3NPC1RAB9A | |
| SCHEMBL3208737 | 0.89 | RORC (0.47) | RORCDHODHCCR3NPC1RAB9A | |
| SCHEMBL3214027 | 0.89 | RORC (0.47) | RORCDHODHCCR3NPC1RAB9A | |
| SCHEMBL3198747 | 0.85 | RORC (0.44) | P2RY1EPHX2CLK2DYRK1AFPR2 | |
| SCHEMBL3198451 | 0.85 | CACNA1G (0.43) | RORCDHODHCCR3 | |
| SCHEMBL3214394 | 0.82 | RORC (0.47) | RORCDHODHCCR3NPC1RAB9A | |
| SCHEMBL3209497 | 0.82 | RORC (0.47) | RORCDHODHCCR3NPC1RAB9A | |
| SCHEMBL401299 | 0.82 | P2RY1 (0.44) | P2RY1EPHX2CLK2DYRK1AFPR2 | |
| SCHEMBL3197593 | 0.82 | RORC (0.46) | RORCDHODHCCR3KCNH2NPC1 | |
| SCHEMBL3191043 | 0.82 | RORC (0.46) | RORCDHODHCCR3KCNH2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765327-A4 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS INC (US) | 2009-06-17 | — | — | EP | claimed |
| EP-1765327-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | Cytokinetics, Inc. (US) | 2007-03-28 | — | — | EP | claimed |
| WO-2006009726-A2 | SUBSTITUTED UREA DERIVATIVES FOR TREATING CARDIAC DISEASES | CYTOKINETICS, INC. (US) | 2006-01-26 | — | — | WO | claimed |