Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 6/20 | 0.66 |
| ▸ | PTGER2 | P43116 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | SNCA | P37840 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PLAAT3 | P53816 | 2/20 | 0.45 |
| ▸ | PLAAT5 | Q96KN8 | 2/20 | 0.45 |
| ▸ | PLAAT2 | Q9NWW9 | 2/20 | 0.45 |
| ▸ | PLAAT4 | Q9UL19 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4302915 | 0.89 | PTGER4 (0.55) | PTGER4NPC1RAB9ASNCASMN1; SMN2 | |
| SCHEMBL4313641 | 0.86 | SNCA (0.49) | PTGER4NPC1RAB9ASNCASMN1; SMN2 | |
| SCHEMBL2351632 | 0.80 | PTGER4 (1.00) | PTGER4PTGER2 | |
| SCHEMBL4088746 | 0.79 | PTGER4 (0.61) | PTGER4PTGER2MAPTMAPK1 | |
| SCHEMBL8218590 | 0.70 | NPC1 (0.71) | NPC1RAB9ASMN1; SMN2HTTTRPV1 | |
| SCHEMBL4089584 | 0.70 | PTGER4 (0.82) | PTGER4PTGER2 | |
| SCHEMBL7888363 | 0.70 | RAB9A (0.51) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL3519296 | 0.69 | GAA (0.46) | NPC1RAB9ASMN1; SMN2GAAMAPT | |
| SCHEMBL8162947 | 0.69 | HIF1A (0.72) | NPC1RAB9ASMN1; SMN2HTTTRPV1 | |
| SCHEMBL7282271 | 0.68 | HDAC2 (0.78) | NPC1RAB9ASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054401-A1 | THIOPHENECARBOXAMIDE DERIVATIVES AS EP4 RECEPTOR LIGANDS | Merck Frosst Canada Ltd. (CA) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008017164-A1 | THIOPHENECARBOXAMIDE DERIVATIVES AS EP4 RECEPTOR LIGANDS | MERCK FROSST CANADA LTD. (CA) | 2008-02-14 | — | — | WO | disclosed |