Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 6/20 | 0.49 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.49 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | CNR1 | P21554 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.41 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.41 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.41 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4304151 | 0.86 | PTGER4 (0.66) | SNCAPTGER4RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4302915 | 0.83 | PTGER4 (0.55) | SNCAPTGER4RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4090073 | 0.80 | PTGER4 (0.76) | PTGER4MAPT | |
| SCHEMBL4088746 | 0.73 | PTGER4 (0.61) | PTGER4LMNAMAPT | |
| SCHEMBL1154126 | 0.67 | TMPRSS4 (0.59) | SNCAEGLN2CNR1HTTLMNA | |
| SCHEMBL14502263 | 0.67 | HDAC2 (0.68) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2351632 | 0.66 | PTGER4 (1.00) | PTGER4 | |
| SCHEMBL3644787 | 0.65 | TRPV1 (0.61) | RAB9ANPC1SMN1; SMN2HTTLMNA | |
| SCHEMBL6316429 | 0.65 | ALDH1A1 (0.66) | RAB9ANPC1CNR1SMN1; SMN2HTT | |
| SCHEMBL2001284 | 0.64 | CNR1 (0.58) | RAB9ACNR1HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054401-A1 | THIOPHENECARBOXAMIDE DERIVATIVES AS EP4 RECEPTOR LIGANDS | Merck Frosst Canada Ltd. (CA) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008017164-A1 | THIOPHENECARBOXAMIDE DERIVATIVES AS EP4 RECEPTOR LIGANDS | MERCK FROSST CANADA LTD. (CA) | 2008-02-14 | — | — | WO | disclosed |