Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | KDM4B | O94953 | 1/20 | 0.35 |
| ▸ | KDM5C | P41229 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | HCK | P08631 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.32 |
| ▸ | PRKDC | P78527 | 1/20 | 0.32 |
| ▸ | IP6K1 | Q92551 | 3/20 | 0.31 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7417525 | 0.85 | ADORA3 (0.46) | ADORA3KDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL5351059 | 0.82 | ADORA3 (0.43) | ADORA3KDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL5595775 | 0.77 | ADORA3 (0.44) | ADORA3KDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL7062655 | 0.72 | ADORA3 (0.55) | ADORA3KDM4AKDM4BKDM5CKDM5B | |
| Hydrochloric Acid SCHEMBL30194697 | 0.70 | ADORA3 (0.54) | ADORA3KDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL21272824 | 0.65 | ADORA3 (0.51) | ADORA3KDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL7422510 | 0.64 | ADORA3 (0.48) | ADORA3PIK3CDABL1EGFRHCK | |
| SCHEMBL7419559 | 0.64 | ADORA3 (0.48) | ADORA3PIK3CDABL1EGFRHCK | |
| SCHEMBL15650225 | 0.62 | — | — | |
| SCHEMBL7468020 | 0.61 | ADORA3 (0.66) | ADORA3KDM4AKDM4BKDM5CKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024272-A2 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | Renovis, Inc. (US) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007133637-A2 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | RENOVIS, INC. (US) | 2007-11-22 | — | — | WO | disclosed |