Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.48 |
| ▸ | HPRT1 | P00492 | 4/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | CFTR | P13569 | 2/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | SCN1A | P35498 | 1/20 | 0.32 |
| ▸ | PDE6C | P51160 | 1/20 | 0.32 |
| ▸ | PDE1A | P54750 | 1/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7422510 | 1.00 | ADORA3 (0.48) | ADORA3HPRT1ADORA2AADORA2BCFTR | |
| SCHEMBL21272824 | 0.78 | ADORA3 (0.51) | ADORA3HPRT1ADORA2AADORA2BCYP1A2 | |
| SCHEMBL364844 | 0.78 | ADORA3 (0.50) | ADORA3HPRT1ADORA2AADORA2BPDE4A | |
| SCHEMBL19208631 | 0.71 | ADORA3 (0.51) | ADORA3HPRT1KDM4EHPGDRAB9A | |
| SCHEMBL19208420 | 0.71 | KDM4E (0.44) | ADORA3HPRT1TSHRKDM4EHPGD | |
| SCHEMBL7062655 | 0.70 | ADORA3 (0.55) | ADORA3KDM4EHPGDRAB9ASMN1; SMN2 | |
| SCHEMBL7417524 | 0.69 | ADORA3 (0.47) | ADORA3HPRT1ADORA2AADORA2BPDE4A | |
| SCHEMBL7416914 | 0.69 | ADORA3 (0.49) | ADORA3HPRT1ADORA2AADORA2BPDE4A | |
| SCHEMBL7416789 | 0.68 | ADORA3 (0.42) | ADORA3HPRT1KDM4EHPGDRAB9A | |
| Hydrochloric Acid SCHEMBL30194697 | 0.68 | ADORA3 (0.54) | ADORA3KDM4EHPGDRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1220856-A2 | PYRAZOLO[4,3-D]PYRIMIDINE DERIVATIVES | Pfizer Limited (GB) | 2002-07-10 | — | — | EP | claimed |
| WO-2001027113-A2 | PYRAZOLO `4,3-d! PYRIMIDINE DERIVATIVES | PFIZER LIMITED (GB) | 2001-04-19 | — | — | WO | claimed |