Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 0.69 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CCR3 | P51677 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.46 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5247343 | 0.91 | HSD11B1 (0.70) | HSD11B1EPHX2MEN1KMT2AL3MBTL1 | |
| SCHEMBL4531620 | 0.86 | HSD11B1 (0.58) | HSD11B1EPHX2MEN1KMT2AALDH1A1 | |
| SCHEMBL5244789 | 0.85 | HSD11B1 (0.58) | HSD11B1EPHX2MEN1KMT2AALDH1A1 | |
| SCHEMBL4537246 | 0.84 | HSD11B1 (0.56) | HSD11B1EPHX2MEN1KMT2ATP53 | |
| SCHEMBL4010674 | 0.83 | HSD11B1 (0.90) | HSD11B1EPHX2TSHR | |
| SCHEMBL4007664 | 0.83 | HSD11B1 (0.90) | HSD11B1EPHX2TSHR | |
| SCHEMBL4010679 | 0.83 | HSD11B1 (0.90) | HSD11B1EPHX2TSHR | |
| SCHEMBL5950314 | 0.83 | HSD11B1 (0.90) | HSD11B1EPHX2TSHR | |
| SCHEMBL5950609 | 0.83 | HSD11B1 (0.90) | HSD11B1EPHX2TSHR | |
| SCHEMBL4531616 | 0.82 | HSD11B1 (0.54) | HSD11B1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778229-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-06-17 | — | — | EP | disclosed |
| EP-1778229-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006020598-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-23 | — | — | WO | disclosed |