Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 2/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.47 |
| ▸ | CYP2E1 | P05181 | 8/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.47 |
| ▸ | CYP2C8 | P10632 | 8/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 8/20 | 0.47 |
| ▸ | CYP2B6 | P20813 | 8/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4307803 | 0.89 | CYP1A2 (0.51) | SLC2A1ALDH1A1NPC1TP53HPGD | |
| SCHEMBL29386273 | 0.83 | RAB9A (0.66) | ALDH1A1NPC1TP53HPGDSMN1; SMN2 | |
| SCHEMBL28437897 | 0.83 | RAB9A (0.66) | ALDH1A1NPC1TP53HPGDSMN1; SMN2 | |
| SCHEMBL4312658 | 0.82 | PDE3B (0.45) | SLC2A1ALDH1A1NPC1TP53HPGD | |
| SCHEMBL4305121 | 0.80 | CYP1A2 (0.50) | ALDH1A1NPC1TP53HPGDSMN1; SMN2 | |
| SCHEMBL4312005 | 0.77 | CYP1A2 (0.48) | ALDH1A1NPC1TP53HPGDSMN1; SMN2 | |
| SCHEMBL4662315 | 0.77 | PTGDR2 (0.40) | ALDH1A1SMN1; SMN2MEN1POLBKMT2A | |
| SCHEMBL1905967 | 0.75 | RAB9A (0.71) | ALDH1A1NPC1TP53SMN1; SMN2MEN1 | |
| SCHEMBL30705213 | 0.75 | RAB9A (0.71) | ALDH1A1NPC1TP53SMN1; SMN2MEN1 | |
| SCHEMBL12635909 | 0.73 | F10 (0.61) | ALDH1A1NPC1TP53HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090062280-A1 | Ophthalmic Compositions for Treating Ocular Hypertension | MERCK SHARP & DOHME CORP. | 2009-03-05 | — | — | US | disclosed |
| EP-2004193-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | Merck & Co., Inc. (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007108968-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO., INC. (US) | 2007-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062280-A1 | Ophthalmic Compositions for Treating Ocular Hypertension | KCNN3, KCNN1, KCNN2 | CBFB 1648/4885SLC2A1 938/4885ALDH1A1 1707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.