Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 7/20 | 0.71 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.71 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.71 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.68 |
| ▸ | MEN1 | O00255 | 4/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.68 |
| ▸ | MAPT | P10636 | 3/20 | 0.68 |
| ▸ | HPGD | P15428 | 3/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.68 |
| ▸ | USP2 | O75604 | 1/20 | 0.68 |
| ▸ | TP53 | P04637 | 1/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.68 |
| ▸ | HTR1B | P28222 | 1/20 | 0.64 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.64 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.64 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13913892 | 0.92 | ALDH1A1 (0.80) | ADORA1ADORA2BADORA3ADORA2AALDH1A1 | |
| SCHEMBL13913906 | 0.90 | ADORA2B (0.74) | ADORA1ADORA2BADORA3ADORA2AALDH1A1 | |
| SCHEMBL13913908 | 0.87 | ALDH1A1 (0.63) | ADORA1ADORA2BADORA3ADORA2AALDH1A1 | |
| SCHEMBL13913746 | 0.87 | ADORA1 (0.80) | ADORA1ADORA2BADORA3ADORA2AALDH1A1 | |
| SCHEMBL4318226 | 0.87 | ADORA1 (0.70) | ADORA1ADORA2BADORA3ADORA2AALDH1A1 | |
| SCHEMBL13913902 | 0.86 | ALDH1A1 (0.60) | ADORA1ADORA2BADORA3ADORA2AALDH1A1 | |
| SCHEMBL13913772 | 0.85 | ALDH1A1 (0.75) | ADORA1ADORA2BADORA3ADORA2AALDH1A1 | |
| SCHEMBL13913903 | 0.85 | ADORA1 (0.64) | ADORA1ADORA2BADORA2AALDH1A1KDM4E | |
| SCHEMBL13913886 | 0.85 | MEN1 (0.70) | ADORA1ADORA2BADORA3ADORA2AALDH1A1 | |
| SCHEMBL13913896 | 0.85 | ALDH1A1 (0.59) | ADORA1ADORA2BADORA3ADORA2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504421-B2 | Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-03-17 | — | — | US | disclosed |
| US-7504421-B2 | Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-03-17 | — | — | US | disclosed |
| US-7504421-B2 | Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-03-17 | — | — | US | disclosed |
| US-20060264432-A1 | Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2006-11-23 | — | — | US | disclosed |
| US-7135486-B1 | Adenosine A1, A2a, and A2b receptor ligands; coupling the 2-mercapto-3,5-dicyano-4-aryl-6-aminopyridine to a substituted alkyl or alkenyl compound; antiischemic agents; cardiovascular disorders | BAYER AKTIENGESELISCHAFT (DE) | 2006-11-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264432-A1 | Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use | ADORA2B, ADORA2A, ADORA1 | ADORA1 3/4885ADORA2B 1/4885ADORA3 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.