SCHEMBL4309019

SCHEMBL4309019

N=NC(Cc1c[nH]c2ccccc12)C(=O)O

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.65
KDM4E B2RXH2 3/20 0.63
MAPT P10636 3/20 0.63
KMT2A Q03164 3/20 0.63
L3MBTL1 Q9Y468 2/20 0.63
MEN1 O00255 2/20 0.63
POLB P06746 2/20 0.63
APAF1 O14727 1/20 0.63
RECQL P46063 1/20 0.63
LMNA P02545 1/20 0.63
MPO P05164 1/20 0.63
TSHR P16473 1/20 0.63
BLM P54132 1/20 0.63
PMP22 Q01453 1/20 0.63
HIF1A Q16665 1/20 0.63
DNMT1 P26358 3/20 0.55
CYP2C19 P33261 1/20 0.54
DNMT3B Q9UBC3 1/20 0.54
PKM P14618 1/20 0.54
ALOX15 P16050 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4309022 1.00 SMN1; SMN2 (0.65) SMN1; SMN2KDM4EMAPTKMT2AL3MBTL1
SCHEMBL2945686 0.87 SMN1; SMN2 (0.67) SMN1; SMN2KDM4EMAPTKMT2AL3MBTL1
SCHEMBL2945687 0.87 SMN1; SMN2 (0.67) SMN1; SMN2KDM4EMAPTKMT2AL3MBTL1
SCHEMBL10701840 0.86 SMN1; SMN2 (0.65) SMN1; SMN2KDM4EMAPTKMT2AL3MBTL1
SCHEMBL2491934 0.86 SMN1; SMN2 (0.65) SMN1; SMN2KDM4EMAPTKMT2AL3MBTL1
SCHEMBL10701837 0.86 SMN1; SMN2 (0.65) SMN1; SMN2KDM4EMAPTKMT2AL3MBTL1
SCHEMBL31036050 0.83 SMN1; SMN2 (0.62) SMN1; SMN2KDM4EMAPTKMT2AL3MBTL1
SCHEMBL27367040 0.83 SMN1; SMN2 (0.62) SMN1; SMN2KDM4EMAPTKMT2AL3MBTL1
SCHEMBL30661929 0.83 SMN1; SMN2 (0.62) SMN1; SMN2KDM4EMAPTKMT2AL3MBTL1
SCHEMBL27577681 0.83 SMN1; SMN2 (0.62) SMN1; SMN2KDM4EMAPTKMT2AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4203948-A1 COMPOSITIONS AND USES THEREOF Purposeful, Ike (GR) 2023-07-05 EP claimed
WO-2022079304-A1 COMPOSITIONS AND USES THEREOF PURPOSEFUL IKE (GR) 2022-04-21 WO claimed
EP-4203948-A1 COMPOSITIONS AND USES THEREOF Purposeful, Ike (GR) 2023-07-05 EP disclosed
US-11446398-B2 Regulated biocircuit systems OBSIDIAN THERAPEUTICS, INC. (US) 2022-09-20 US disclosed
WO-2022079304-A1 COMPOSITIONS AND USES THEREOF PURPOSEFUL IKE (GR) 2022-04-21 WO disclosed
US-20210254056-A1 IDENTIFICATION AND TARGETED MODULATION OF GENE SIGNALING NETWORKS CAMP4 THERAPEUTICS CORPORATION 2021-08-19 US disclosed
US-10877035-B2 Advanced drug development and manufacturing ICAGEN, LLC (US) 2020-12-29 US disclosed
US-20190192691-A1 REGULATED BIOCIRCUIT SYSTEMS OBSIDIAN THERAPEUTICS, INC. 2019-06-27 US disclosed
WO-2018204764-A1 IDENTIFICATION AND TARGETED MODULATION OF GENE SIGNALING NETWORKS CAMP4 THERAPEUTICS CORPORATION (US) 2018-11-08 WO disclosed
US-20150309021-A1 Advanced Drug Development and Manufacturing LOS ALAMOS NATIONAL SECURITY, LLC 2015-10-29 US disclosed
EP-2511844-B1 X-ray microscope XRPRO SCIENCES INC (US) 2015-08-12 EP disclosed
EP-2511844-A2 Advanced drug development and manufacturing Los Alamos National Security, LLC (US) 2012-10-17 EP disclosed
EP-2084519-B1 X-RAY FLUORESCENCE ANALYSIS METHOD LOS ALAMOS NAT SECURITY LLC (US) 2012-08-01 EP disclosed
EP-2084519-A2 ADVANCED DRUG DEVELOPMENT AND MANUFACTURING Los Alamos National Security, LLC (US) 2009-08-05 EP disclosed
WO-2008127291-A2 ADVANCED DRUG DEVELOPMENT AND MANUFACTURING LOS ALAMOS NATIONAL SECURITY, LLC (US) 2008-10-23 WO disclosed
US-20080220441-A1 Advanced drug development and manufacturing THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2008-09-11 US disclosed