Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.49 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | CA2 | P00918 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16346002 | 0.85 | TSHR (0.62) | LOXL2MEN1KMT2AMAPK1CYP4A11 | |
| SCHEMBL1198228 | 0.83 | LOXL2 (0.63) | LOXL2MEN1KMT2AMAPK1CYP4A11 | |
| SCHEMBL1811745 | 0.78 | LOXL2 (0.61) | LOXL2MEN1KMT2AMAPK1CYP4A11 | |
| SCHEMBL20259350 | 0.77 | LOXL2 (0.66) | LOXL2MEN1KMT2AMAPK1CYP4A11 | |
| SCHEMBL28902573 | 0.77 | LOXL2 (0.56) | LOXL2MEN1KMT2AMAPK1CYP4A11 | |
| SCHEMBL28312233 | 0.77 | LOXL2 (0.56) | LOXL2MEN1KMT2AMAPK1CYP4A11 | |
| SCHEMBL14332763 | 0.75 | TSHR (0.67) | MEN1KMT2AMAPK1TSHRALDH1A1 | |
| SCHEMBL211335 | 0.75 | LOXL2 (0.63) | LOXL2MEN1KMT2AMAPK1CYP4A11 | |
| SCHEMBL7151482 | 0.75 | LOXL2 (0.63) | LOXL2MEN1KMT2AMAPK1CYP4A11 | |
| SCHEMBL3622207 | 0.75 | LOXL2 (0.64) | LOXL2MEN1KMT2AMAPK1CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090012075-A1 | Fluorinated Arylamide Derivatives | MERCK SHARP & DOHME CORP. | 2009-01-08 | — | — | US | disclosed |
| EP-1976511-A2 | FLUORINATED ARYLAMIDE DERIVATIVES | Merck & Co., Inc. (US) | 2008-10-08 | — | — | EP | disclosed |
| WO-2007087129-A2 | FLUORINATED ARYLAMIDE DERIVATIVES | MERCK & CO., INC. (US) | 2007-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012075-A1 | Fluorinated Arylamide Derivatives | HDAC5, AADAC, HDAC6 | LOXL2 1529/4885MEN1 2902/4885KMT2A 27/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.