SCHEMBL16346002

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL4901678	0.86	TSHR (0.81)	TSHRCYP4A11CYP4F2TDP1MEN1
	SCHEMBL4312014	0.85	LOXL2 (0.53)	TSHRLOXL2CYP4A11CYP4F2TDP1
	SCHEMBL1198228	0.84	LOXL2 (0.63)	TSHRLOXL2CYP4A11CYP4F2TDP1
	SCHEMBL19134100	0.83	TSHR (0.57)	TSHRCYP4A11CYP4F2TDP1MEN1
	SCHEMBL14010060	0.82	TSHR (0.70)	TSHRCYP4A11CYP4F2TDP1MEN1
	SCHEMBL13800480	0.80	CA1 (0.70)	TSHRLOXL2CYP4A11CYP4F2TDP1
	SCHEMBL5646360	0.79	LOXL2 (0.58)	TSHRLOXL2CYP4A11CYP4F2TDP1
	SCHEMBL317876	0.79	TSHR (0.66)	TSHRTDP1KMT2AKLK7
	SCHEMBL5175026	0.79	TSHR (0.76)	TSHRMEN1KMT2ACA2KLK7
	SCHEMBL9626909	0.79	TSHR (0.70)	TSHRTDP1MEN1KMT2ACA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.