SCHEMBL4312419

SCHEMBL4312419

CCCCC1=C(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)CN(Cc2cccc(F)c2F)C(C)=N1

nearest known ligand 0.48

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PPARG P37231 11/20 0.48
AGTR1 P30556 3/20 0.48
SLC33A1 O00400 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4011388 0.92 PPARG (0.49) PPARGAGTR1SLC33A1
SCHEMBL4009430 0.89 PPARG (0.49) PPARGAGTR1SLC33A1
SCHEMBL4305728 0.86 PPARG (0.53) PPARGAGTR1
SCHEMBL4302459 0.84 AGTR1 (0.52) PPARGAGTR1SLC33A1
SCHEMBL4011112 0.84 PPARG (0.53) PPARGAGTR1SLC33A1
SCHEMBL4016594 0.84 SLC33A1 (0.54) PPARGAGTR1SLC33A1
SCHEMBL4010324 0.84 PPARG (0.44) PPARGAGTR1
SCHEMBL4011449 0.83 SLC33A1 (0.53) PPARGAGTR1SLC33A1
SCHEMBL4012946 0.81 SLC33A1 (0.51) PPARGAGTR1SLC33A1
SCHEMBL4010276 0.81 AGTR1 (0.49) PPARGAGTR1SLC33A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009133970-A1 CRYSTALLINE COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-11-05 WO disclosed