Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14949662 | 1.00 | POLB (0.49) | POLBGFERFFAR1ALDH1A1MAPT | |
| SCHEMBL12892585 | 0.88 | MAPT (0.46) | POLBFFAR1ALDH1A1MAPTLMNA | |
| SCHEMBL14949653 | 0.88 | POLB (0.42) | POLBGFERFFAR1ALDH1A1MAPT | |
| SCHEMBL14949654 | 0.88 | POLB (0.42) | POLBGFERFFAR1ALDH1A1MAPT | |
| SCHEMBL14949660 | 0.85 | POLB (0.39) | POLBMAPTKMT2ACA12CA1 | |
| SCHEMBL14949661 | 0.85 | POLB (0.39) | POLBMAPTKMT2ACA12CA1 | |
| SCHEMBL1258095 | 0.81 | NR3C1 (0.46) | ALDH1A1LMNASMN1; SMN2GAA | |
| SCHEMBL1258097 | 0.81 | NR3C1 (0.46) | ALDH1A1LMNASMN1; SMN2GAA | |
| SCHEMBL3486084 | 0.81 | POLB (0.47) | POLBALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL3486085 | 0.81 | POLB (0.47) | POLBALDH1A1MAPTKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445509-B2 | Fused heterocyclic derivatives and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-05-21 | — | — | US | disclosed |
| WO-2009136663-A1 | FUSED HETEROCYCLIC DERIVATIVES AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-12 | — | — | WO | disclosed |