Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 5/20 | 0.39 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14949654 | 1.00 | POLB (0.42) | POLBFFAR1METPLA2G7ALDH1A1 | |
| SCHEMBL4312914 | 0.88 | POLB (0.49) | POLBFFAR1ALDH1A1GAAMEN1 | |
| SCHEMBL14949662 | 0.88 | POLB (0.49) | POLBFFAR1ALDH1A1GAAMEN1 | |
| SCHEMBL14949660 | 0.84 | POLB (0.39) | POLBMEN1KMT2AMAPTKDR | |
| SCHEMBL14949661 | 0.84 | POLB (0.39) | POLBMEN1KMT2AMAPTKDR | |
| SCHEMBL1258045 | 0.82 | NR3C1 (0.37) | ALDH1A1TP53KMT2A | |
| SCHEMBL12892585 | 0.77 | MAPT (0.46) | POLBFFAR1ALDH1A1TP53TSHR | |
| SCHEMBL13623158 | 0.76 | MGAT2 (0.38) | POLBTP53KMT2AMAPT | |
| SCHEMBL1321460 | 0.75 | POLB (0.45) | POLBALDH1A1MEN1KMT2ARXFP1 | |
| SCHEMBL12119821 | 0.75 | POLB (0.45) | POLBALDH1A1MEN1KMT2ARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445509-B2 | Fused heterocyclic derivatives and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-05-21 | — | — | US | disclosed |