Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 1/20 | 0.37 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.36 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.36 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.36 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | BDKRB1 | P46663 | 3/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13881866 | 1.00 | CETP (0.37) | CETPABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL14615245 | 0.86 | CETP (0.37) | CETPBDKRB1 | |
| SCHEMBL13881859 | 0.86 | CETP (0.41) | CETPBDKRB1 | |
| SCHEMBL4306551 | 0.86 | CETP (0.41) | CETPBDKRB1 | |
| SCHEMBL5107148 | 0.81 | CFTR (0.44) | CETP | |
| SCHEMBL5103357 | 0.81 | CFTR (0.44) | CETP | |
| SCHEMBL4308440 | 0.80 | CETP (0.36) | CETPBDKRB1HDAC3HDAC6 | |
| SCHEMBL4315855 | 0.79 | ALDH1A1 (0.40) | EPHX2HPGDRXFP1PPARDPPARA | |
| SCHEMBL4194984 | 0.78 | SUCNR1 (0.41) | CETPHDAC3HDAC6 | |
| SCHEMBL4460827 | 0.78 | SUCNR1 (0.41) | CETPHDAC3HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090088458-A1 | N-(Pyridin-4-Yl)-2-Phenylbutanamides as Androgen Receptor Modulators | MERCK SHARP & DOHME CORP. | 2009-04-02 | — | — | US | claimed |
| EP-1912945-A1 | N-(PYRIDIN-4-YL)-2-PHENYLBUTANAMIDES AS ANDROGEN RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2008-04-23 | — | — | EP | claimed |
| WO-2007016358-A1 | N-(PYRIDIN-4-YL)-2-PHENYLBUTANAMIDES AS ANDROGEN RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2007-02-08 | — | — | WO | claimed |
| US-20090088458-A1 | N-(Pyridin-4-Yl)-2-Phenylbutanamides as Androgen Receptor Modulators | MERCK SHARP & DOHME CORP. | 2009-04-02 | — | — | US | disclosed |
| US-20090088458-A1 | N-(Pyridin-4-Yl)-2-Phenylbutanamides as Androgen Receptor Modulators | MERCK SHARP & DOHME CORP. | 2009-04-02 | — | — | US | disclosed |
| US-20090088458-A1 | N-(Pyridin-4-Yl)-2-Phenylbutanamides as Androgen Receptor Modulators | MERCK SHARP & DOHME CORP. | 2009-04-02 | — | — | US | disclosed |
| EP-1912945-A1 | N-(PYRIDIN-4-YL)-2-PHENYLBUTANAMIDES AS ANDROGEN RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007016358-A1 | N-(PYRIDIN-4-YL)-2-PHENYLBUTANAMIDES AS ANDROGEN RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2007-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090088458-A1 | N-(Pyridin-4-Yl)-2-Phenylbutanamides as Androgen Receptor Modulators | SHBG, AR, NR5A1 | CETP 3677/4885ABCC9 4627/4885ABCC8 4785/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.