Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 7/20 | 0.40 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4315474 | 1.00 | AURKA (0.55) | AURKAAURKBCHEK1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL4311739 | 0.95 | AURKA (0.52) | AURKAAURKBCHEK1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL4311725 | 0.95 | AURKA (0.52) | AURKAAURKBCHEK1NPC1RAB9A | |
| SCHEMBL4307856 | 0.93 | AURKA (0.55) | AURKAAURKBCHEK1NPC1RAB9A | |
| SCHEMBL4307860 | 0.93 | AURKA (0.55) | AURKAAURKBCHEK1NPC1RAB9A | |
| SCHEMBL4314052 | 0.90 | AURKA (0.57) | AURKAAURKBNPC1RAB9AFGFR1 | |
| SCHEMBL4314044 | 0.90 | AURKA (0.57) | AURKAAURKBNPC1RAB9AFGFR1 | |
| SCHEMBL4308993 | 0.87 | AURKA (0.55) | AURKAAURKBCHEK1NPC1RAB9A | |
| SCHEMBL4308986 | 0.87 | AURKA (0.55) | AURKAAURKBCHEK1NPC1RAB9A | |
| SCHEMBL4317454 | 0.87 | AURKA (0.57) | AURKAAURKBNPC1RAB9AFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7605272-B2 | IGF-1R inhibitor | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2009-10-20 | — | — | US | disclosed |
| US-20090054508-A1 | IGF-1R INHIBITOR | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-02-26 | — | — | US | disclosed |
| EP-1847532-A1 | IGF-1R INHIBITOR | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-10-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054508-A1 | IGF-1R INHIBITOR | IGF1R, IGFBP5, IGFBP1 | AURKA 3687/4885AURKB 3438/4885CHEK1 3274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.