IGFBP5 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL9450837	0.59	8/20
SCHEMBL9319269	0.53	7/20
SCHEMBL2909395	0.51	7/20
SCHEMBL2908228	0.50	7/20
SCHEMBL3328720	0.50	7/20
SCHEMBL11632812	0.54	6/20
SCHEMBL21987014	0.52	6/20
SCHEMBL12803363	0.48	6/20
SCHEMBL12958877	0.48	6/20
SCHEMBL21360633	0.46	6/20
SCHEMBL21360602	0.45	6/20
SCHEMBL21360629	0.45	6/20
SCHEMBL6080457	0.43	6/20
SCHEMBL20030906	0.38	6/20
SCHEMBL2904707	0.50	5/20
SCHEMBL11804167	0.47	5/20
SCHEMBL2907726	0.39	5/20
Hydrochloric Acid (SCHEMBL11803024)	0.46	4/20
SCHEMBL9319235	0.45	4/20
SCHEMBL13271166	0.44	4/20

Clinical trials — most relevant to IGFBP5 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effects of Oral vs. Non-oral Contraceptives on the GH/IGF-1 Axis	PHASE4	COMPLETED
Efficacy of Oral Metformin vs Oral Doxycycline in Treating Acne Vulgaris	PHASE4	COMPLETED
Metformin Use to Reduce Disparities in Newly Diagnosed Breast Cancer	PHASE4	WITHDRAWN
Insulin-like Growth Factor (IGF-I) in Hemodialysis Patients	PHASE4	COMPLETED
Effect of Continuous GHRP-3 Infusion at on GH-IGF-I System, Blood Pressure, Glucose, and Insulin Resistance	PHASE1/PHASE2	WITHDRAWN
Study Assessing Potential Predictive Tumor Markers in Metastatic Colorectal Cancer	PHASE2	COMPLETED
A Prevention Trial in Subjects at High Risk for Breast Cancer	PHASE2	COMPLETED
Effect of Functional Exercise in Patients With Spinal Bulbar Muscular Atrophy	PHASE1/PHASE2	COMPLETED
Pappalysin 2 (PAPP-A2) Enzyme Replacement	PHASE1	COMPLETED
Defined Green Tea Catechins in Treating Patients With Prostate Cancer Undergoing Surgery to Remove the Prostate	PHASE1	COMPLETED
Chinese Herbal Formulation PHY906 and Sorafenib Tosylate in Treating Patients With Advanced Liver Cancer	PHASE1	COMPLETED
Estradiol-Receptor Blockade in Older Men and Women	PHASE1	COMPLETED
Prognostic Value of Protein IMP3 Expression in Cervical Cancer	nan	COMPLETED
Genetic Study of Insulin-Like Growth Factor-I Receptor Mutations in Patients With Intrauterine Growth Retardation	nan	UNKNOWN
Metabolic and Inflammatory Responses to Hemodialysis and the Effect of a Meal	nan	COMPLETED
Assessment of the Diagnostic Role of Serum Insulin-like Growth Factor Binding Protein-3 as a Potential Biomarker for Colorectal Cancer (CRC) in Egypt	nan	NOT_YET_RECRUITING
Effects of Standardized Meals on the Metabolic, Hormonal and Inflammatory Responses in Human	nan	COMPLETED
To Assess the Level of Adherence of Subjects Receiving SAIZEN® Via Easypod™ in the UK	nan	COMPLETED
Using IGF-1 for Nutritional Monitoring	nan	COMPLETED
Biomarkers Related to Bone in Pediatric Gaucher Disease	nan	UNKNOWN
Metabolic and Hormonal Effects of 5:2 Intermittent Fasting	nan	COMPLETED
Epidemiology of Insulin Growth Factor (IGF) and Cardiovascular Events	nan	COMPLETED
Follow-up to Adult Height of a Cohort of Subjects Born Small for the Gestational Age and Treated With Growth Hormone	nan	COMPLETED
Can Do Versus Do Do in Patients With Breast Cancer	nan	COMPLETED
Adipocytokines in Endometrial Cancer	nan	COMPLETED
A Low-Insulinemic Dietary Intervention to Reduce Breast Cancer Risk in High-Risk Women	nan	COMPLETED
Effect of a Low-Calorie Diet and/or Exercise Program on Risk Factors for Developing Breast Cancer in Overweight or Obese Postmenopausal Women	nan	COMPLETED
Role of Biomarkers in Endometrial Cancer Recurrence in Samples From Patients With Stage II, Stage III, or Stage IV Endometrial Cancer	nan	UNKNOWN
The IGFBP-3 Stimulation Test: A New Tool for the Diagnosis of Growth Hormone Deficiency in Children.	nan	COMPLETED
Effect of Insulin Sensitization on IGF-1 Response to Growth Hormone in SGA Children	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a IGFBP5 binder may also engage these)

Protein	Name	Similarity
P24594	—	1.000	P24594 →
Q28985	—	1.000	Q28985 →
Q07079	—	1.000	Q07079 →
Q05717	—	1.000	Q05717 →
Q90WV8	—	0.994	Q90WV8 →
Q5XHC5	—	0.993	Q5XHC5 →
P47879	—	0.992	P47879 →
P21744	—	0.991	P21744 →
IGFBP3	Insulin-like growth factor-binding protein 3	0.990	landscape →
Q9PTH3	—	0.988	Q9PTH3 →
P21743	—	0.988	P21743 →
P47876	—	0.988	P47876 →
P47878	—	0.988	P47878 →
B3F211	—	0.987	B3F211 →
Q29400	—	0.987	Q29400 →
P12843	—	0.987	P12843 →
P47877	—	0.987	P47877 →
Q6Q484	—	0.986	Q6Q484 →
IGFBP2	Insulin-like growth factor-binding protein 2	0.985	landscape →
IGFBP4	Insulin-like growth factor-binding protein 4	0.984	landscape →
Q9ES72	—	0.984	Q9ES72 →
IGFBP1	Insulin-like growth factor-binding protein 1	0.984	landscape →
P15473	—	0.983	P15473 →
P49705	—	0.983	P49705 →
P24591	—	0.983	P24591 →
P20959	—	0.982	P20959 →
P19336	—	0.981	P19336 →
Q05716	—	0.981	Q05716 →
A4IIA2	—	0.980	A4IIA2 →
P24853	—	0.979	P24853 →