Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 8/20 | 0.45 |
| ▸ | TGFB2 | P61812 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.32 |
| ▸ | HTR3B | O95264 | 1/20 | 0.32 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.32 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27761145 | 0.87 | TGFBR1 (0.45) | TGFBR1TGFB2RECQLIRAK4MAPT | |
| SCHEMBL2011373 | 0.86 | TGFBR1 (0.42) | TGFBR1TGFB2RECQLIRAK4KDM4E | |
| SCHEMBL2009561 | 0.74 | TGFBR1 (0.51) | TGFBR1TGFB2RECQLIRAK4MAPT | |
| SCHEMBL17328622 | 0.74 | TGFBR1 (0.51) | TGFBR1TGFB2RECQLIRAK4MAPT | |
| SCHEMBL24095415 | 0.72 | TGFBR1 (0.43) | TGFBR1TGFB2IRAK4 | |
| SCHEMBL2012430 | 0.71 | MAPT (0.42) | TGFBR1RECQLIRAK4KDM4ELMNA | |
| SCHEMBL9405312 | 0.66 | IRAK4 (0.37) | TGFBR1IRAK4 | |
| SCHEMBL20028700 | 0.65 | SMN1; SMN2 (0.56) | RECQLKDM4ELMNATP53GAA | |
| SCHEMBL27382529 | 0.64 | TGFBR1 (0.47) | TGFBR1TGFB2IRAK4TSHRMAPT | |
| SCHEMBL7038679 | 0.63 | CCR1 (0.41) | RECQLKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074128-A1 | THERAPEUTIC PYRAZOLYL THIENOPYRIDINES | Pfizer Products Incorporated (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008047198-A1 | THERAPEUTIC PYRAZOLYL THIENOPYRIDINES | PFIZER PRODUCTS INC. (US) | 2008-04-24 | — | — | WO | disclosed |