Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 7/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | TGFB2 | P61812 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 9/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.37 |
| ▸ | HTR3B | O95264 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2009561 | 0.82 | TGFBR1 (0.51) | TGFBR1RECQLTGFB2MAPTIRAK4 | |
| SCHEMBL4315973 | 0.74 | TGFBR1 (0.45) | TGFBR1RECQLTGFB2MAPTIRAK4 | |
| SCHEMBL27761145 | 0.72 | TGFBR1 (0.45) | TGFBR1RECQLTGFB2MAPTIRAK4 | |
| SCHEMBL2011373 | 0.71 | TGFBR1 (0.42) | TGFBR1RECQLTGFB2MAPTIRAK4 | |
| SCHEMBL27382529 | 0.71 | TGFBR1 (0.47) | TGFBR1TGFB2MAPTIRAK4HTR3E | |
| SCHEMBL23873841 | 0.69 | TGFBR1 (0.54) | TGFBR1IRAK4 | |
| SCHEMBL24095415 | 0.69 | TGFBR1 (0.43) | TGFBR1TGFB2IRAK4 | |
| SCHEMBL20979001 | 0.69 | TGFBR1 (0.61) | TGFBR1 | |
| SCHEMBL24142605 | 0.68 | HTR3E (0.44) | TGFBR1RECQLMAPTIRAK4HTR3E | |
| SCHEMBL22822531 | 0.67 | TGFBR1 (0.67) | TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2527345-B1 | Therapeutic pyrazolyl thienopyridines | THESAN PHARMACEUTICALS INC (US) | 2015-12-16 | — | — | EP | disclosed |