Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 9/20 | 0.85 |
| ▸ | TUBB4A | P04350 | 8/20 | 0.85 |
| ▸ | TUBB | P07437 | 8/20 | 0.85 |
| ▸ | TUBA3C | P0DPH7 | 8/20 | 0.85 |
| ▸ | TUBA1B | P68363 | 8/20 | 0.85 |
| ▸ | TUBA4A | P68366 | 8/20 | 0.85 |
| ▸ | TUBB4B | P68371 | 8/20 | 0.85 |
| ▸ | TUBB3 | Q13509 | 8/20 | 0.85 |
| ▸ | TUBB2A | Q13885 | 8/20 | 0.85 |
| ▸ | TUBB8 | Q3ZCM7 | 8/20 | 0.85 |
| ▸ | TUBA3E | Q6PEY2 | 8/20 | 0.85 |
| ▸ | TUBA1A | Q71U36 | 8/20 | 0.85 |
| ▸ | TUBA1C | Q9BQE3 | 8/20 | 0.85 |
| ▸ | TUBB6 | Q9BUF5 | 8/20 | 0.85 |
| ▸ | TUBB2B | Q9BVA1 | 8/20 | 0.85 |
| ▸ | TOP2A | P11388 | 1/20 | 0.72 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12091271 | 1.00 | TUBB1 (0.85) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL23824196 | 0.93 | TUBB1 (0.82) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL23293736 | 0.93 | TUBB1 (0.82) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL23824139 | 0.93 | TUBB4A (0.73) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL12091312 | 0.93 | TUBB4A (0.73) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL23824193 | 0.93 | TUBB4A (0.81) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| Thiocolchicine SCHEMBL43161 | 0.92 | TUBB1 (1.00) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| Thiocolchicine SCHEMBL43160 | 0.92 | TUBB1 (1.00) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL12973828 | 0.91 | TUBB1 (0.81) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL31238349 | 0.91 | TUBB1 (0.81) | TUBB1TUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210283092-A1 | METHODS AND USES OF COLCHICINE DERIVATIVES | ALBERTA HEALTH SERVICES (CA) | 2021-09-16 | — | — | US | disclosed |
| US-20210283092-A1 | METHODS AND USES OF COLCHICINE DERIVATIVES | ALBERTA HEALTH SERVICES (CA) | 2021-09-16 | — | — | US | disclosed |
| EP-3813821-A1 | METHODS AND USES OF COLCHICINE DERIVATIVES | Alberta Health Services (CA) | 2021-05-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210283092-A1 | METHODS AND USES OF COLCHICINE DERIVATIVES | IL1B, IL6, TUBB | TUBB1 4/4885TUBB4A 18/4885TUBB 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.