Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 4/20 | 0.67 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.67 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4316071 | 1.00 | AURKA (0.67) | AURKAAURKBS1PR1PDE10AMEN1 | |
| SCHEMBL4316060 | 1.00 | AURKA (0.67) | AURKAAURKBS1PR1PDE10AMEN1 | |
| SCHEMBL4316067 | 1.00 | AURKA (0.67) | AURKAAURKBS1PR1PDE10AMEN1 | |
| SCHEMBL4310581 | 0.93 | AURKA (0.67) | AURKAAURKBMEN1KMT2AL3MBTL1 | |
| SCHEMBL4310588 | 0.93 | AURKA (0.67) | AURKAAURKBMEN1KMT2AL3MBTL1 | |
| SCHEMBL4310284 | 0.92 | AURKA (0.67) | AURKAAURKBMEN1KMT2AL3MBTL1 | |
| SCHEMBL4310294 | 0.92 | AURKA (0.67) | AURKAAURKBMEN1KMT2AL3MBTL1 | |
| SCHEMBL4310288 | 0.92 | AURKA (0.67) | AURKAAURKBMEN1KMT2AL3MBTL1 | |
| SCHEMBL4310280 | 0.92 | AURKA (0.67) | AURKAAURKBMEN1KMT2AL3MBTL1 | |
| SCHEMBL4307940 | 0.92 | AURKA (0.66) | AURKAAURKBMEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1847532-B1 | IGF-1R INHIBITOR | KYOWA HAKKO KIRIN CO LTD (JP) | 2013-06-05 | — | — | EP | claimed |
| EP-1847532-B1 | IGF-1R INHIBITOR | KYOWA HAKKO KIRIN CO LTD (JP) | 2013-06-05 | — | — | EP | disclosed |
| US-7605272-B2 | IGF-1R inhibitor | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2009-10-20 | — | — | US | disclosed |
| US-20090054508-A1 | IGF-1R INHIBITOR | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-02-26 | — | — | US | disclosed |
| EP-1847532-A1 | IGF-1R INHIBITOR | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-10-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054508-A1 | IGF-1R INHIBITOR | IGF1R, IGFBP5, IGFBP1 | AURKA 3687/4885AURKB 3438/4885S1PR1 701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.