Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 4/20 | 0.55 |
| ▸ | FLT1 | P17948 | 3/20 | 0.55 |
| ▸ | ITK | Q08881 | 1/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | LGMN | Q99538 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CBFB | Q13951 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4317893 | 1.00 | FGFR1 (0.55) | FGFR1FLT1ITKLRRK2PDGFRB | |
| SCHEMBL4326947 | 0.91 | FGFR1 (0.53) | FGFR1FLT1ITKLRRK2PDGFRB | |
| SCHEMBL4326946 | 0.91 | FGFR1 (0.53) | FGFR1FLT1ITKLRRK2PDGFRB | |
| SCHEMBL4327057 | 0.83 | FGFR1 (0.42) | FGFR1FLT1ITKLRRK2PDGFRB | |
| SCHEMBL4327051 | 0.83 | FGFR1 (0.42) | FGFR1FLT1ITKLRRK2PDGFRB | |
| SCHEMBL27691469 | 0.83 | FGFR1 (0.51) | FGFR1FLT1ITKLRRK2PDGFRB | |
| SCHEMBL4312073 | 0.83 | FGFR1 (0.41) | FGFR1FLT1ITKLRRK2PDGFRB | |
| SCHEMBL4312068 | 0.83 | FGFR1 (0.41) | FGFR1FLT1ITKLRRK2PDGFRB | |
| SCHEMBL27691456 | 0.83 | FGFR1 (0.41) | FGFR1FLT1ITKLRRK2PDGFRB | |
| SCHEMBL4317941 | 0.81 | FGFR1 (0.42) | FGFR1FLT1LRRK2AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7605272-B2 | IGF-1R inhibitor | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2009-10-20 | — | — | US | disclosed |
| US-20090054508-A1 | IGF-1R INHIBITOR | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-02-26 | — | — | US | disclosed |
| EP-1847532-A1 | IGF-1R INHIBITOR | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-10-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054508-A1 | IGF-1R INHIBITOR | IGF1R, IGFBP5, IGFBP1 | FGFR1 18/4885FLT1 81/4885ITK 1951/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.