Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | PGR | P06401 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.47 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Coenzyme Q1 SCHEMBL1129498 | 0.86 | LMNA (0.73) | LMNAMAPTTDP1PGRMAPK1 | |
| SCHEMBL2625087 | 0.82 | LMNA (0.68) | LMNAMAPTTDP1PGRMAPK1 | |
| SCHEMBL16999349 | 0.81 | LMNA (0.62) | LMNAMAPTTDP1PGRMAPK1 | |
| SCHEMBL18715960 | 0.80 | LMNA (0.72) | LMNAMAPTTDP1PGRMAPK1 | |
| SCHEMBL11874455 | 0.79 | IDO1 (0.51) | LMNAMAPTTDP1PGRMAPK1 | |
| SCHEMBL16999348 | 0.78 | LMNA (0.59) | LMNAMAPTTDP1PGRMAPK1 | |
| SCHEMBL16999350 | 0.78 | LMNA (0.59) | LMNAMAPTTDP1PGRMAPK1 | |
| SCHEMBL14407307 | 0.78 | LMNA (0.62) | LMNAMAPTTDP1PGRMAPK1 | |
| SCHEMBL14407313 | 0.78 | LMNA (0.62) | LMNAMAPTTDP1PGRMAPK1 | |
| SCHEMBL10822606 | 0.77 | LMNA (0.69) | LMNAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2042502-A1 | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor | JAPAN TOBACCO INC. (JP) | 2009-04-01 | — | — | EP | disclosed |
| EP-1758581-A1 | COMBINATIONS COMPRISING A 4-ISOQUINOLONE DERIVATIVE AND ANTI-HIV AGENTS | Japan Tobacco, Inc. (JP) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005112930-A1 | COMBINATIONS COMPRISING A 4-ISOQUINOLONE DERIVATIVE AND ANTI-HIV AGENTS | JAPAN TOBACCO INC. (JP) | 2005-12-01 | — | — | WO | disclosed |